Exercise-Induced Urticaria: When People are Allergic to Physical Activity

Amazing stuff! I think I am allergic to allergies! 😊 I guess the good news is that it is very rare. Maybe it is even a medical curiosity.

Could this become a good excuse to avoid physical exercise? 😊

"... First described in the 1970s, exercise-induced urticaria is a relatively rare condition likely due to a sudden increase in the body’s core temperature.

Scientists propose that mast cell degranulation and a rise in plasma histamine levels are involved. In extreme cases, people may experience a systemic reaction where tissues beyond the skin are involved, such as anaphylaxis. The condition can be managed with a regimen of antihistamines and epinephrine administration if required. ...

Another working theory is that an increase in temperature activates the sympathetic nervous system, which is involved in the fight-or-flight response. This stimulates nerve fibers to release the neurotransmitter acetylcholine, leading to mast cell degranulation, and consequently secrete histamine. ..."

Exercise-Induced Urticaria: When People are Allergic to Physical Activity | The Scientist "Some people experience an itchy skin rash or hives after exercising because of immune responses activated by a rise in body temperature."

Figure 2: Urticaria on abdomen within 20 minutes of the onset of the exercise (Source)