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"... Now, researchers ... engineered human stomach organoids to secrete insulin. Transplanting these into diabetic mice reduced hyperglycemia.2 Their findings, published today in Stem Cell Reports, could help develop technologies to engineer a person’s own insulin-secreting cells for diabetes treatment. ..."
From the highlights and abstract:
"Highlights
• Engrafted human gastric organoids (hGOs) model human stomach in vivo
• NPM factor induction converts hGOs into insulin+ β-like cells in vitro and in vivo
• In situ gastric reprogramming offers potential for autologous diabetes cell therapy
Summary
Insulin-dependent diabetes could be treated by supplying patients with primary pancreatic islets or other types of insulin-secreting cells. Functional insulin-secreting cells can be induced in situ from the murine stomach using defined genetic factors, offering a promising method to directly produce autologous insulin-secreting cells.
Here, we modeled whether such gastric insulin-secreting (GINS) cells could be generated in vivo from human stomach tissues. We produced human gastric organoids (hGOs) from human embryonic stem cells engineered with inducible expression of reprogramming factors.
The hGOs were stably transplanted for 6 months and showed robust cytodifferentiation resembling the human stomach in structure and cellular composition.
Upon hGO maturation in vivo, we activated the reprogramming factors and observed the formation of insulin+ cells, which secreted insulin into the circulation and ameliorated experimental diabetes.
Our modeling indicates that GINS cells can be induced from human stomach tissues in vivo, warranting further therapeutic development for this technology."
Figure 1 Generation of hGOs from hESCs with inducible expression of NPM factors
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