Wednesday, November 26, 2025

The human brain goes through five distinct phases and four major turning points during lifetime

Amazing stuff! What about age 100 and older? 😊

"Your brain goes through five distinct phases with pivotal turning points at ages 9, 32, 66, and 83, with researchers finding adolescence actually lasts until your early thirties."

"... The brain goes through five distinct phases in life, with key turning points at ages nine, 32, 66 and 83, scientists have revealed.

Around 4,000 people up to the age of 90 had scans to reveal the connections between their brain cells.

Researchers at the University of Cambridge showed that the brain stays in the adolescent phase until our early thirties when we "peak". ..."

"Neuroscientists at the University of Cambridge have identified five “major epochs” of brain structure over the course of a human life, as our brains rewire to support different ways of thinking while we grow, mature, and ultimately decline.  ..."

From the abstract:
"Structural topology develops non-linearly across the lifespan and is strongly related to cognitive trajectories. We gathered diffusion imaging from datasets with a collective age range of zero to 90 years old (N = 4,216).
We analyzed how 12 graph theory metrics of organization change with age and projected these data into manifold spaces using Uniform Manifold Projection and Approximation.
With these manifolds, we identified four major topological turning points across the lifespan – around nine, 32, 66, and 83 years old. These ages defined five major epochs of topological development, each with distinctive age-related changes in topology.
These lifespan epochs each have a distinct direction of topological development and specific changes in the organizational properties driving the age-topology relationship. This study underscores the complex, non-linear nature of human development, with unique phases of topological maturation, which can only be illuminated with a multivariate, lifespan, population-level perspective."

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Fig. 1: Datasets demographics, methods schematic, and network connectivity.


Fig. 2: Changes in total network connectivity across the lifespan.


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