I would say something to be aware of when undergoing any kind of cancer treatment!
"A large international study of more than 23,000 patients has found that common medicines used to treat high blood pressure and cholesterol, as well as heartburn, may be impacting cancer treatment effectiveness. ...
Researchers from the University of South Australia (UniSA) were looking at whether everyday drugs used to treat chronic health conditions could potentially affect treatment for breast cancer, and what they found was a "concerning" pattern when it came to certain medications.
Anaylzing data from 19 breast cancer clinical trials, featuring 23,211 patients, the researchers discovered that one class of drug in particular – proton-pump inhibitors (PPIs), used to treat indigestion and heartburn – was associated with poorer overall survival, progression-free survival and a 36% increased risk of serious adverse events during treatment. ..."
From the abstract:
"Background
The impact of commonly used non-cancer medications on breast cancer outcomes remains underexplored in large datasets.
Aims
To evaluate the associations between commonly used non-cancer medications and survival as well as adverse events in patients with breast cancer.
Materials & Methods
Individual participant data from 19 breast cancer clinical trials (n = 23,211) were pooled. Cox proportional hazards models and logistic regression analyses were used to assess associations between medication use and overall survival, progression-free survival and grade ≥ 3 adverse events. Analyses were adjusted for demographic, cancer and comorbidity factors.
Results
Proton pump inhibitor use was associated with poorer overall survival (HR 1.19, 95% CI: 1.08–1.30), progression-free survival (HR 1.11, 95% CI: 1.02–1.21) and an increased risk of grade ≥ 3 adverse events (OR 1.36, 95% CI: 1.21–1.53).
Beta-blockers, ACE inhibitors/ARBs and calcium channel blockers were linked with higher adverse event rates but showed no significant impact on survival.
Statins and metformin demonstrated no significant associations with either survival or adverse events.
Conclusion
These findings emphasise the need for careful management of concomitant medications in breast cancer care and support ongoing research to optimise treatment safety and efficacy."
Common heartburn and blood pressure medicines linked to adverse breast cancer outcomes (original news release)
Associations of Commonly Used Concomitant Medications With Survival and Adverse Event Outcomes in Breast Cancer (open access)
Fig. 1 PPI Forest Plot.
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