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"... Some of these problems stem from failures in the proper recognition, adhesion, and fusion of sperm and an egg. A key part of the process involves IZUMO1, a protein on the surface of sperm cells, and JUNO, a receptor on the egg. The IZUMO1-JUNO connection enables sperm and egg recognition and fusion. ...
For the study, the researchers analyzed the X-ray crystal structure of IZUMO1 as it came in contact with OBF13. The researchers found that OBF13 attaches itself to sperm in such a way that it reconfigures the way sperm come into contact with an egg. The analysis also identified a high-affinity (tightly bonding) variant of OBF13 that potently blocks egg-sperm fertilization.
In addition, the researchers identified key amino acid sites on JUNO that define its ability to bind with IZUMO1. When accessed, these sites are able to bind sperm and egg for fertilization despite interference from OBF13 or its variant.
“In this work, we are reporting the first anti-sperm antibody-antigen complex structure,” Tang said. “We provide high-resolution information that will open avenues for discovering IZUMO1 regulators, guide antibody and small-molecule inhibitor design, and support drug screening for contraceptive development.” ..."
P.S. Unfortunately, the article does not contain neither the title of the study nor a link to the study.
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