Good news, but slow progress! Positive results seem mixed. Only four individuals involved in this trial.
"A paralysed man can stand on his own after receiving an injection of neural stem cells to treat his spinal cord injury. The Japanese man was one of four individuals in a first-of-its-kind trial that used reprogrammed stem cells to treat people who are fully paralysed.
Another man can now move his arms and legs following the treatment, but the two others did not show substantial improvements. The results were announced at a press conference and have not yet been peer reviewed, but they suggest that the treatment is safe, say researchers."
"... Previous trials using other types of stem cell have also demonstrated that the therapy is safe, but have so far shown mixed results. “Nothing’s really worked so far,” ...
In this trial, iPS cells derived from a donor were used to create neural precursor cells. Two million of these were injected into each patient’s injury site, in the hope that they would eventually develop into neurons and glial cells.
The trial’s first surgery was performed in December 2021; the other three were conducted between 2022 and 2023. All four recipients were adult males and two were aged 60 or older. They all had surgery between two and four weeks after the damage was done ...
At the one-year follow-up, the researchers did not observe any serious adverse effects.
All individuals started the trial with the highest injury classification of A, as measured by the American Spinal Injury Association Impairment Scale (AIS). People with this level of impairment have no sensory or motor function below the point of injury.
Two of the participants did not show improvements in their ability to feel or move in the lowest section of their spinal cord.
One individual moved up to a classification of C in the period after surgery, and can move some of their arm and leg muscles but cannot stand on their own. Another individual improved to a level D (normal function is classified as E) and can stand independently. ..."
Paralysed man stands again after receiving ‘reprogrammed’ stem cells (limite public access) "Another man also regained some movement, but two others experienced minimal improvement."
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