Good news!
"A breakthrough imaging technique is transforming the treatment of drug-resistant epilepsy by enabling doctors to pinpoint elusive brain lesions. ...
ultra-powerful MRI scanners are now identifying subtle differences in brain tissue that were previously undetectable, prompting a reassessment of treatment plans for 58% of patients in a recent study. ..."
From the abstract:
"Objective
To implement parallel transmit (pTx) 7T magnetic resonance imaging (MRI) in the pre-surgical evaluation of 3T-negative patients with drug-resistant focal epilepsy, and to compare quality to conventional single transmit (specifically, circularly polarized [CP]) 7T MRI.
Methods
We implemented a comparative protocol comprising both pTx and CP 7T MRI in consecutive adult candidates for epilepsy surgery who had negative or equivocal 3T MRI imaging. Here we report the outcomes from the first 31 patients. We acquired pTx and CP T1, T2, fluid-attenuated inversion recovery (FLAIR) and edge-enhancing gradient echo (EDGE) images, all in the same three-dimensional (3D) 0.8 mm isotropic space. Two-dimensional (2D) high-resolution T2 and T2*-weighted sequences were acquired only in CP mode due to current technological limitations. Two neuroradiologists, a neurologist, and a neurosurgeon made independent, blinded quality and preference ratings of pTx vs CP images. Quantitative methods were used to assess signal dropout.
Results
7T revealed previously-unseen structural lesions in nine patients (29%), confirmed 3T-equivocal lesions in four patients (13%), and disproved 3T-equivocal lesions in four patients (13%).
Lesions were better visualized on pTx than CP in 57% of cases, and never better visualized on CP.
Clinical management was altered by 7T in 18 cases (58%).
Nine cases were offered surgical resection and one laser interstitial thermal therapy (LITT).
Three cases were removed from the surgical pathway because of bilateral or extensive lesions.
Five cases were offered stereo-electroencephalography (sEEG) with better targeting (in three because the 7T lesion was deemed equivocal by the multi-disciplinary team (MDT), and in two because the lesion was extensive).
Blinded comparison confirmed significantly better overall quality of pTx FLAIR images (F(2, 184) = 13.7, p = 2.88 × 10−6), whereas pTx MP2RAGE images were subjectively non-inferior and had improved temporal lobe coverage with quantitatively less signal drop-out.
Significance
pTx-7T is implementable in a clinical pathway, changed management in 58% of patients where 3T + FDG-PET had not enabled resection, and is superior to single transmit 7T MRI."
Powerful new MRI scans enable life-changing surgery in first for adults with epilepsy (original news release 1) "Scientists have used a new technique that has enabled ultra-powerful magnetic resonance imaging (MRI) scanners to identify tiny differences in patients’ brains that cause treatment-resistant epilepsy. The first study to use this approach, it has allowed doctors at Addenbrooke’s Hospital, Cambridge, to offer the patients surgery to cure their condition."
Ultra-powerful MRI study offers hope for people with hard-to-treat epilepsy (original news release 2)
Comparison of images produced using existing 3T MRI imaging (left) and parallel transmit 7T MRI (right). Both images show a side view of the brain with close ups shown in the inset frames.
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