Sunday, March 30, 2025

Bizarre, reversible brain "shrink" seen in long-distance runners

Bad news if confirmed! Extreme sports can be unhealthy!

Note it takes weeks if not months to recover from the loss of myelin after a marathon rung.

"... researchers warn that going the distance may not be so good for the brain – with the negative effects lingering for a month following a race. ...

Scientists ... have identified a link between marathon running and a sharp reduction in the protective myelin that surrounds nerve fibers – axons – in the brain. This insulating layer is critical for facilitating the transmission of electrical signals in the brain and spinal cord – and a loss of myelin is one biomarker of many neurological conditions, including stroke and multiple sclerosis. ...

In this observational study, the researchers examined MRI brain scans of runners before the race and then again within 48 hours of completing the grueling 26.2-mile (42.195-km) route. They found that in a dozen areas of the brain, in regions associated with motor coordination, senses and emotions, myelin had been noticeably depleted following a race. ...

further scans showed that myelin had naturally increased two weeks after the run, and then had returned to normal levels after two months. ..."

Bizarre brain "shrink" seen in long-distance runners

Reversible reduction in brain myelin content after endurance exercise (no public access) "We observed that an MRI surrogate of myelin content, myelin water fraction, is reduced in white matter regions after marathon running but recovers later. These findings suggest that brain myelin content is reversibly reduced after prolonged exercise, consistent with evidence in rodents that myelin lipids provide energy under extreme metabolic conditions."

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