The research on DNA based computers continues!
"... DNA is rather fragile to work with, it can be hard to reliably write to, read from, move and process information on it. But the new study claims to have developed a new system that can solve those problems. The key is a soft polymer material that acts like a scaffold for the DNA, which can be dehydrated for long term storage and rehydrated for retrieval. ...
To write data to the DNA, algorithms first convert it into sequences of nucleic acids – the familiar ACGT letters of DNA code. Specific pieces of information can be retrieved using RNA molecules that copy the data from the DNA, and then sequencing that RNA. That means you don’t have to destroy the DNA to read back from it, unlike some existing DNA data techniques. ..."
To write data to the DNA, algorithms first convert it into sequences of nucleic acids – the familiar ACGT letters of DNA code. Specific pieces of information can be retrieved using RNA molecules that copy the data from the DNA, and then sequencing that RNA. That means you don’t have to destroy the DNA to read back from it, unlike some existing DNA data techniques. ..."
"Researchers f... have demonstrated a technology capable of a suite of data storage and computing functions – repeatedly storing, retrieving, computing, erasing or rewriting data – that uses DNA rather than conventional electronics. Previous DNA data storage and computing technologies could complete some but not all of these tasks. ..."
From the abstract:
"... Here we present a DNA-based store and compute engine that captures these primordial capabilities. This system comprises multiple image files encoded into DNA and adsorbed onto ~50-μm-diameter, highly porous, hierarchically branched, colloidal substrate particles comprised of naturally abundant cellulose acetate. Their surface areas are over 200 cm2 mg−1 with binding capacities of over 1012 DNA oligos mg−1, 10 TB mg−1 or 104 TB cm−3. This ‘dendricolloid’ stably holds DNA files better than bare DNA with an extrapolated ability to be repeatedly lyophilized and rehydrated over 170 times compared with 60 times, respectively. Accelerated ageing studies project half-lives of ~6,000 and 2 million years at 4 °C and −18 °C, respectively. The data can also be erased and replaced, and non-destructive file access is achieved through transcribing from distinct synthetic promoters. The resultant RNA molecules can be directly read via nanopore sequencing and can also be enzymatically computed to solve simplified 3 × 3 chess and sudoku problems. Our study establishes a feasible route for utilizing the high information density and parallel computational advantages of nucleic acids."
For First Time, DNA Tech Offers Both Data Storage and Computing Functions (original news release)
A primordial DNA store and compute engine (no public access)
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