Good news! Cancer is history (soon)!
Nature journal also uses this awful, ideological language of "people with breast cancer". It is women!!!! It is so annoying!!! Disgusting!
"The sensory nerves responsible for touch, taste, sight and smell help breast cancer infiltrate other regions of the body — but an anti-nausea drug already in use might block this interaction. Researchers found that growing sensory neurons next to mouse cancer cells caused them to produce a molecule called substance P. This neuropeptide is also present in high levels in human breast tumours that have spread to the lymph nodes. An anti-nausea medication used to treat chemotherapy side effects called aprepitant blocks this nerve-cancer interaction in mice and cell cultures, slowing the spread of cancer."
"... the paper, published today [8/7/2024] in Nature, is the latest in a wave of discoveries about the relationship between cancer and the nervous system. The finding is unique, however, in that these ‘sensory’ nerves seem to be interacting directly with tumours to aid the cancer’s spread, rather than triggering immune responses that then encourage tumour formation and growth. ..."
From the abstract:
"Tumour innervation is associated with worse patient outcomes in multiple cancers, which suggests that it may regulate metastasis. Here we observed that highly metastatic mouse mammary tumours acquired more innervation than did less-metastatic tumours. This enhanced innervation was driven by expression of the axon-guidance molecule SLIT2 in tumour vasculature. Breast cancer cells induced spontaneous calcium activity in sensory neurons and elicited release of the neuropeptide substance P (SP). Using three-dimensional co-cultures and in vivo models, we found that neuronal SP promoted breast tumour growth, invasion and metastasis. Moreover, patient tumours with elevated SP exhibited enhanced lymph node metastatic spread. SP acted on tumoral tachykinin receptors (TACR1) to drive death of a small population of TACR1high cancer cells. Single-stranded RNAs (ssRNAs) released from dying cells acted on neighbouring tumoural Toll-like receptor 7 (TLR7) to non-canonically activate a prometastatic gene expression program. This SP- and ssRNA-induced Tlr7 gene expression signature was associated with reduced breast cancer survival outcomes. Therapeutic targeting of this neuro–cancer axis with the TACR1 antagonist aprepitant, an approved anti-nausea drug, suppressed breast cancer growth and metastasis in multiple models. Our findings reveal that tumour-induced hyperactivation of sensory neurons regulates multiple aspects of metastatic progression in breast cancer through a therapeutically targetable neuropeptide/extracellular ssRNA sensing axis."
Breast-cancer cells enlist nerves to spread throughout the body "Surprising results show that ‘sensory’ nerves, which carry information to the brain, have a direct role in helping tumours to metastasize."
Breast cancer cells (artificially coloured) are more likely to spread from tumours that include more nerve fibres than from those with fewer such fibres.
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