Good news! Demand for kidney transplants far exceeds supply! Not to mention that there are also individuals selling their kidneys.
The last name of the recipient speaks volumes: Richard “Rick” Slayman
"The renowned Boston teaching hospital announced the world’s first successful transplant today of a genetically edited pig kidney into a 62-year-old ... man living with end-stage kidney disease. ...
Nearly seven decades after the first successful kidney transplant ...
The cutting-edge CRISPR technology was pivotal in this operation, Mass General said.
The pig kidney was provided by eGenesis of Cambridge from a pig donor that was “genetically-edited using CRISPR-Cas9 technology to remove harmful pig genes and add certain human genes to improve its compatibility with humans,” the hospital added in a press release this morning. ...
MGH identified the patient as Richard “Rick” Slayman of Weymouth, who is “recovering well” and is expected to be discharged soon. ..."
"... More than 800,000 people in the U.S., and millions globally, suffer from end-stage renal disease or kidney failure, a life-threatening condition for which transplantation is considered the gold standard treatment option to improve quality of life and outcomes. Yet the demand for organs far outpaces supply, with more than 90,000 individuals on the kidney waitlist and approximately 25,000 kidney transplants performed each year. ...
The eGenesis donor kidney (EGEN-2784) used for this procedure is the company’s lead candidate for kidney transplant and carries three classes of edits:
The eGenesis donor kidney (EGEN-2784) used for this procedure is the company’s lead candidate for kidney transplant and carries three classes of edits:
(1) knock out of three genes involved in the synthesis of glycan antigens implicated in hyperacute rejection,
(2) insertion of seven human transgenes involved in the regulation of pathways that modulate rejection: inflammation, innate immunity, coagulation, and complement, and
(3) inactivation of the endogenous retroviruses in the porcine genome.
eGenesis is the only company in the industry developing organs that carry all three classes of edits to address organ safety and efficacy. Without genetic modification, a porcine kidney would be immediately rejected by a human recipient. ..."
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