Pop a pill! Who needs exercise? (Caution: Irony)
"A drug that stimulates muscles to burn fuel as if they're exercising has been found to reduce fat mass in obese mice.
Developed by researchers in the US, the compound belongs to a proposed class of therapeutics known as exercise mimetics, that has been mostly tested in animals and is yet to be approved. ...
In a previous study, published earlier this year, ... team showed their compound, SLU-PP-332, increased a specific type of muscle fibre in mice and enhanced exercise endurance. The normal-weight mice ran further and longer than untreated mice, as if the drug had unlocked new energy stores.
In this new study, ... The researchers noticed that within two hours of administering the compound to mice, it prompted the animals' muscles to switch over to burning more fats like they would with prolonged exercise. ...
In subsequent experiments with obese mice, the animals had similarly reduced fat mass after 28 days of treatment but also an average weight loss of about 12 percent. They simply expended more energy while resting. ..."
From the abstract:
"Physical exercise induces physiological adaptations and is effective at reducing the risk of premature death from all causes. Pharmacological exercise mimetics may be effective in the treatment of a range of diseases including obesity and metabolic syndrome. Previously, we described the development of SLU-PP-332, an agonist for the ERRa, b and g nuclear receptors that activates an acute aerobic exercise program. Here, we examine the effects of this exercise mimetic in mouse models of obesity and metabolic syndrome. Diet-induced obese or ob/ob mice were administered SLU-PP-332 and the effects on a range of metabolic parameters were assessed. SLU-PP-332 administration mimics exercise-induced benefits on whole-body metabolism in mice including increased energy expenditure and fatty acid oxidation. These effects were accompanied by decreased fat mass accumulation. Additionally, the ERR agonist effectively reduced obesity and improved insulin sensitivity in models of metabolic syndrome. Pharmacological activation of ERR may be an effective method to treat metabolic syndrome and obesity."
A Synthetic ERR Agonist Alleviates Metabolic Syndrome (no public access)
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