Saturday, May 01, 2021

Bacteria May Aid Anti-Melanoma Cancer Immune Response

Good news! This seems to be early research, but promising!

"... bacteria residing within tumor cells. ... researchers ... have discovered that the immune system "sees" these bacteria and shown they can be harnessed to provoke an immune reaction against the tumor. ...
Immunotherapy treatments of the past decade or so have dramatically improved recovery rates from certain cancers, particularly malignant melanoma; but in melanoma, they still work in only about 40% of the cases. ...
The HLA [human leukocyte antigen
] peptidomics analysis revealed nearly 300 peptides from 41 different bacteria on the surface of the melanoma cells. ..."

"A variety of species of bacteria are known to colonize human tumours proliferate within them and modulate immune function, which ultimately affects the survival of patients with cancer and their responses to treatment ...
Our study reveals that peptides derived from intracellular bacteria can be presented by tumour cells and elicit immune reactivity, and thus provides insight into a mechanism by which bacteria influence activation of the immune system and responses to therapy."

Bacteria May Aid Anti-Cancer Immune Response The findings of a new study may explain the microbiome-immunotherapy connection

Here is the link to the underlying research article:

Did you know that melanoma can look so pretty:


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