Good news! Sounds like this could be a breakthrough! Cancer is history!
"... Now, a new, best-of-both-worlds approach packages the cancer-killing power of chemotherapy and the long-term efficacy of immunotherapy into a biomaterial-based cancer vaccine that can be injected adjacent to a tumor site. When mice with aggressive triple-negative breast cancer (TNBC) were given the vaccine, 100% of them survived a subsequent injection of cancer cells without relapsing. This research is reported in Nature Communications. ...
First developed in 2009, the injectable cancer vaccine has shown great promise in treating multiple types of cancer in mice, and has been explored in clinical trials for treating melanoma at Dana Farber Cancer Institute. In the original formulation of the vaccine, molecules found in cancerous cells called tumor-associated antigens (TAAs) were incorporated together with adjuvants inside the aspirin-sized scaffold so that arriving dendritic cells could recognize them as “foreign” and mount an immune response targeted against the tumor."
First developed in 2009, the injectable cancer vaccine has shown great promise in treating multiple types of cancer in mice, and has been explored in clinical trials for treating melanoma at Dana Farber Cancer Institute. In the original formulation of the vaccine, molecules found in cancerous cells called tumor-associated antigens (TAAs) were incorporated together with adjuvants inside the aspirin-sized scaffold so that arriving dendritic cells could recognize them as “foreign” and mount an immune response targeted against the tumor."
"Poorly immunogenic tumors, including triple negative breast cancers (TNBCs), remain resistant to current immunotherapies, due in part to the difficulty of reprogramming the highly immunosuppressive tumor microenvironment (TME). Here we show that peritumorally injected, macroporous alginate gels loaded with granulocyte-macrophage colony-stimulating factor (GM-CSF) for concentrating dendritic cells (DCs), CpG oligonucleotides, and a doxorubicin-iRGD conjugate enhance the immunogenic death of tumor cells, increase systemic tumor-specific CD8 + T cells, repolarize tumor-associated macrophages towards an inflammatory M1-like phenotype, and significantly improve antitumor efficacy against poorly immunogenic TNBCs.
This system also prevents tumor recurrence after surgical resection and results in 100% metastasis-free survival upon re-challenge. ..."
This system also prevents tumor recurrence after surgical resection and results in 100% metastasis-free survival upon re-challenge. ..."
Here is the respective research paper:
Biomaterial-based scaffold for in situ chemo-immunotherapy to treat poorly immunogenic tumors | Nature Communications
Biomaterial-based scaffold for in situ chemo-immunotherapy to treat poorly immunogenic tumors | Nature Communications
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