Physical attacks on a political candidate for the highest office in a Western democracy are a very serious matter!
Monday, December 06, 2021
Populist Presidential Hopeful Zemmour in France Attacked at Rally, 39 Antifa Arrests
Covid’s Three Blind Mice: Anthony Fauci, Deborah Birx, and Robert Redfield
Very recommendable! A long book review article! The whole article is full of incredible events, stupid decisions etc. Finally, we learn more who was behind this colossal federal government failure with respect to the SARS-CoV-2/Covid-19 response and what they did!
It is an incredible story! The Faucian bargain comes to light! Apparently, Anthony Fauci already failed and was discredited decades ago as far as the AIDS epidemic was concerned!!!
Unfortunately, for President Trump and Vice President Pence not to fire these three quacks in time was a huge mistake!
"How could public officials vowing to “follow the science” on Covid-19 persist in promoting ineffective strategies with terrible consequences? In a memoir of his time on the White House Coronavirus Task Force, Scott W. Atlas provides an answer: because the nation’s governance was hijacked by three bureaucrats with scant interest in scientific research or debate—and no concern for the calamitous effects of their edicts. ...
Atlas calls them “the troika” because of their strategy for presenting a united front, never disagreeing with one another during the meetings in the White House Situation Room. (Reporting later revealed that they had made a pact to resign in unison if any of them was fired.)
Atlas calls them “the troika” because of their strategy for presenting a united front, never disagreeing with one another during the meetings in the White House Situation Room. (Reporting later revealed that they had made a pact to resign in unison if any of them was fired.)
These veterans of the federal bureaucracy had worked closely together during the AIDS epidemic, and their track record was hardly reassuring. Their long and costly quest to develop an AIDS vaccine ultimately failed, but they did manage to persuade the public that AIDS would spread widely beyond gay men and intravenous drug users. Redfield, with some help from Fauci, was the chief prophet of a “heterosexual breakout,” a threat that terrified Americans for more than a decade but never materialized. ...
Atlas writes, “because I couldn’t believe my ears. ‘So you think people aren’t frightened enough?’ [Fauci] said, ‘Yes, they need to be more afraid.’ To me, this was another moment of Kafkaesque absurdity ...
Atlas writes, “because I couldn’t believe my ears. ‘So you think people aren’t frightened enough?’ [Fauci] said, ‘Yes, they need to be more afraid.’ To me, this was another moment of Kafkaesque absurdity ...
Fauci got the most media attention of the troika, but Atlas thinks that Birx did the most damage. As Pence’s chief subordinate on the Task Force, she shaped its agenda, participated in the regular “Covid huddle” with White House officials, and traveled the country, successfully pressuring state and local leaders to issue mask mandates and close businesses and schools. In one of Atlas’s first meetings with her, he asked her what she considered the strongest scientific evidence for the efficacy of masks against Covid. She cited a report published by the Centers for Disease Control about a hair salon in Missouri, where two stylists infected with Covid had worn masks that supposedly prevented the virus from infecting their customers.
“I knew the study well,” Atlas writes, “having already dissected it in detail with a few epidemiologists before I set foot in Washington. My colleagues had all laughed at it. It was poorly done, and the conclusions were not valid. It was an embarrassment that it had been published prominently on the CDC website.” Among the many limitations of this small study, critics had noted that, while none of the customers contacted by the researchers reported Covid symptoms, most of them were never tested for the virus, and many of the stylists’ customers were never contacted at all. ..."
Eine Chronologie der Beleidigungen gegen "Ungeimpfte"
Die vielen öffentlichen sprachlichen Entgleisungen in der Bananenrepublik sind zutiefst beunruhigend! Die Feindbild Sprache der Nazis ist nach 1945 wiedergekehrt. Das Vergessen hat nach nur etwa drei Generationen eingesetzt! Welch Barberei im sog. Land der Dichter und Denker!
Mit dem Klimawahn kam der Coronawahn! Der Wahn geht um in der Bananenrepublik Deutschland!
Vielen Dank an Tichy's Einblick, dass er dieses Thema so ausführlich behandelt nicht nur mid diesem Artikel!
Wood made foldable and stronger than steel
Amazing stuff! Knock on wood!
"Wood that can be moulded into complex shapes and sculpted into knives sharper than metal ones has been created by the inventors of bullet-proof and fire-retardant wood. ...
But scientists at the University of Maryland in the US have discovered ways to treat hardwood sheets and bulk timber so they can pretty much make whatever you want – nails, knives or honeycomb structures strong enough to support the weight of a car. ...
One of the new methods – treating hardwood sheets so that they can be folded into three-dimensional shapes – is as cost-efficient as making the same shapes with plastic or metal ...
‘We show that a [hardened wood] table knife can be made nearly three times sharper than commercial table knives,’ the researchers wrote. The material can also be used to make wooden nails, which work the same as steel nails but don’t rust. ..."
But scientists at the University of Maryland in the US have discovered ways to treat hardwood sheets and bulk timber so they can pretty much make whatever you want – nails, knives or honeycomb structures strong enough to support the weight of a car. ...
One of the new methods – treating hardwood sheets so that they can be folded into three-dimensional shapes – is as cost-efficient as making the same shapes with plastic or metal ...
‘We show that a [hardened wood] table knife can be made nearly three times sharper than commercial table knives,’ the researchers wrote. The material can also be used to make wooden nails, which work the same as steel nails but don’t rust. ..."
From the two abstracts:
"... We report a processing strategy that uses cell wall engineering to shape flat sheets of hardwood into versatile three-dimensional (3D) structures. After breaking down wood’s lignin component and closing the vessels and fibers by evaporating water, we partially re-swell the wood in a rapid water-shock process that selectively opens the vessels. This forms a distinct wrinkled cell wall structure that allows the material to be folded and molded into desired shapes. The resulting 3D-molded wood is six times stronger than the starting wood and comparable to widely used lightweight materials such as aluminum alloys. ..."
"... We demonstrate a potential low-cost and sustainable hard material made from natural wood. Through a simple and effective approach, bulk natural wood can be processed into a hardened wood (HW) with a 23-fold increase in hardness. To demonstrate the potential applications of HW, we show that an HW table knife can be made nearly three times sharper than commercial table knives. An HW nail can be as functional as a steel nail with comparable performance but is immune from rusting, a key failure mechanism of steel nails. ..."
Lightweight, strong, moldable wood via cell wall engineering as a sustainable structural material (no public access)
Corona: 2G-plus Seilbahnregeln in Bayerns für geimpfte Skifahrer
Wenn Klimawahn und Coronawahn zusammenkommen! Absurdes aus der wahnsinnigen Bananenrepublik Deutschland!
Christine Lambrecht (SPD) wird neue Verteidigungsministerin in der Ampel-Regierung
In der Bananenrepublik Deutschland wird es anscheinend zur Routine Frauen zu Verteidiungsministern zu machen! Frau Lambrecht ist nun die Dritte Frau hintereinander in diesem Amt.
Dabei gibt es noch nicht mal eine allgmeine Wehrpflicht für Frauen in Deutschland! Hat schon mal jemand gegen diese Geschlechterdiskrimierung geklagt? Wieviel militärische Erfahrung hat diese lebenslange Berufspolitikerin und Juristin?
Immerhin wurden ja seit einem Urteil des Europäischen Gerichtshofs von 2001 alle Laufbahnen der Bundeswehr für Frauen geöffnet! "Während 2001 nur etwa 6.700 Soldatinnen in der Bundeswehr dienten, sind es heute rund 23.400. Das entspricht einem Frauenanteil in den militärischen Bereichen von fast 13 Prozent - Tendenz steigend." (Quelle)
Sunday, December 05, 2021
Dining at The World's Largest Synthetic Meat Factory
Very recommendable! Don't feel upside down watching this video! 😄 Visit the Upside Foods meat production facility with the CEO of the company Uma Valeti! The CEO claims his whole family eats synthetic meat and his dog.
It is not like cutting tofu!
The company plans to produce various meat products using biotechnology to induce stem cells to differentiate into muscle tissue, and to manufacture the meat products in bioreactors. (Source)
Klimaschau: Spielt die Sonne beim Klimawandel doch eine größere Rolle als gedacht?
Sehr empfehlenswert! Der Einfluss der Sonne auf das Klima der Erde ist nicht konstant und nicht vernachlässigbar. Leider sind wird das von der Propaganda und Demagogie der Klimawandel Fanatiker bestritten!
On Advancing mathematics by guiding human intuition with AI
A match made in heaven! Expect more to come! Fascinating! Very promising approach! Google again is pushing the envelope!
From the abstract:
"... We propose a process of using machine learning to discover potential patterns and relations between mathematical objects, understanding them with attribution techniques and using these observations to guide intuition and propose conjectures. We outline this machine-learning-guided framework and demonstrate its successful application to current research questions in distinct areas of pure mathematics, in each case showing how it led to meaningful mathematical contributions on important open problems: a new connection between the algebraic and geometric structure of knots, and a candidate algorithm predicted by the combinatorial invariance conjecture for symmetric groups4. Our work may serve as a model for collaboration between the fields of mathematics and artificial intelligence (AI) that can achieve surprising results by leveraging the respective strengths of mathematicians and machine learning."
Neutrinos detected in particle collider for first time at CERN
Amazing stuff!
"... Neutrinos are the most abundant fundamental particles that have mass in the universe and have been detected from many sources, including the sun and cosmic-ray interactions. They are among the least understood particles in the standard model of particle physics, with neutrinos produced within a particle collider having never been directly detected. ..."
From the abstract:
"FASERν at the CERN Large Hadron Collider (LHC) is designed to directly detect collider neutrinos for the first time and study their cross sections at TeV energies, where no such measurements currently exist. In 2018, a pilot detector employing emulsion films was installed in the far-forward region of ATLAS, 480 m from the interaction point, and collected 12.2 fb−1
of proton-proton collision data at a center-of-mass energy of 13 TeV. We describe the analysis of this pilot run data and the observation of the first neutrino interaction candidates at the LHC. This milestone paves the way for high-energy neutrino measurements at current and future colliders."
First neutrino interaction candidates at the LHC (no public access)
Photon-counting CT promises a new era of medical imaging
Good news!
"... But there are still limitations to what conventional CT can achieve in the clinic. For starters, it’s not always possible to image all patients: medical implants, for example, can create image artefacts that inhibit diagnostic accuracy. There are also shortfalls with regard to image reproducibility and standardization, both essential for ongoing evaluation of disease progress. Finally, there’s a growing need for functional data alongside the standard anatomical CT images. ...
The culmination of more than 15 years of research, Naeotom Alpha is the world’s first photon-counting CT scanner. Photon-counting technology enables dramatic improvements in diagnostic imaging, including increased resolution and a reduction in radiation dose by up to 45% over conventional CT detectors. ...
“With photon-counting technology, we move from a two-step conversion process to a single one-step conversion of X-ray photons into an electrical current that generates the medical image,” ... that removing a conversion step increases dose efficiency. “The large difference is that with this new technology, we are able to assess each and any single photon separately, and also assess the energy level of each and any photon.” ..."
The culmination of more than 15 years of research, Naeotom Alpha is the world’s first photon-counting CT scanner. Photon-counting technology enables dramatic improvements in diagnostic imaging, including increased resolution and a reduction in radiation dose by up to 45% over conventional CT detectors. ...
“With photon-counting technology, we move from a two-step conversion process to a single one-step conversion of X-ray photons into an electrical current that generates the medical image,” ... that removing a conversion step increases dose efficiency. “The large difference is that with this new technology, we are able to assess each and any single photon separately, and also assess the energy level of each and any photon.” ..."
EU will Sanierungszwang für Altbauten: Gefährdung von Klimazielen
Dieser Unsinn wird teuer! Für den absurden Klimawahn ist nichts zu teuer! Das Neubauten anderen Vorschriften unterliegen ist wohl akzeptabel, aber Altbauten? Das wird einige negative Konsequenzen mit sich bringen, wenn diese Mindeststandards bindend verabschiedet werden.
"... Die Behörde setzt dabei vor allem auf verpflichtende Mindeststandards für die Energiebilanz. Bis Anfang 2027 sollen Altbauten, wenn sie den Eigentümer wechseln oder neu vermietet werden, mindestens die Effizienzklasse E erreichen. Das gilt nicht nur für Wohnhäuser, sondern auch für Hotels oder Bürogebäude. Bis 2030 sollen die Anforderungen auf die Klasse D und 2033 dann auf C steigen.
Das geht aus einem Entwurf für die Überarbeitung der EU-Energieeffizienzregeln für Gebäude hervor, den die Europäische Kommission Mitte Dezember offiziell vorlegen will. ..."
Antoninus Pius: The Greatest Roman Emperor You’ve Never Heard of
Recommendable! A very unusual emperor indeed! Why we do not know more about him is regrettable!
"... his name has survived in relative obscurity because history is often kinder to ambitious conquerors and great builders than to those who respect liberty and govern with a servant’s heart. ...
One of his first acts as emperor was to annul some of Hadrian’s final decrees. The ailing Roman had condemned an untold number of senators, but Antoninus opted for mercy and freed the men. According to some historians, this is why the Senate bestowed the appellation of “Pius” on Antoninus. ...
He sold off imperial lands, reduced or eliminated superfluous salaries, and lived in his own villas rather than imperial estates. He never even traveled beyond Campania during the course of his reign because he believed he simply could not justify draining the public treasury for travel. ...
Antoninus was frugal in other ways, too. He conscientiously guarded the public treasury while simultaneously reducing confiscations and his subjects’ tax burden. On more than one occasion, he chose to expend personal resources to support the empire. For example, he contributed money to repair Hadrian’s construction projects and, during a famine, he provided free wine, oil, and wheat to the Romans at his own expense. He so prudently managed the state’s finances that when he died, he left the public treasury with a massive surplus—a rarity in old Rome. ...
Unlike many of his predecessors and successors, Antoninus seemed to legitimately care for his subjects and the state. He established an endowment to support poverty-stricken, orphaned girls; he loaned personal money at a four percent interest rate (a low rate at the time) to those in need; he didn’t initiate any Christian persecutions, and he sought to return prestige and respect to the Senate. ..."
One of his first acts as emperor was to annul some of Hadrian’s final decrees. The ailing Roman had condemned an untold number of senators, but Antoninus opted for mercy and freed the men. According to some historians, this is why the Senate bestowed the appellation of “Pius” on Antoninus. ...
He sold off imperial lands, reduced or eliminated superfluous salaries, and lived in his own villas rather than imperial estates. He never even traveled beyond Campania during the course of his reign because he believed he simply could not justify draining the public treasury for travel. ...
Antoninus was frugal in other ways, too. He conscientiously guarded the public treasury while simultaneously reducing confiscations and his subjects’ tax burden. On more than one occasion, he chose to expend personal resources to support the empire. For example, he contributed money to repair Hadrian’s construction projects and, during a famine, he provided free wine, oil, and wheat to the Romans at his own expense. He so prudently managed the state’s finances that when he died, he left the public treasury with a massive surplus—a rarity in old Rome. ...
Unlike many of his predecessors and successors, Antoninus seemed to legitimately care for his subjects and the state. He established an endowment to support poverty-stricken, orphaned girls; he loaned personal money at a four percent interest rate (a low rate at the time) to those in need; he didn’t initiate any Christian persecutions, and he sought to return prestige and respect to the Senate. ..."
For the first time, scientists zoom in on one of the earliest phases of the human embryo
Amazing stuff! Unfortunately, no pictures! Research article is behind paywall!
"... Gastrulation occurs around 14 days or so after the egg is fertilized but everything we know about this essential phase of embryonic development comes from studies on animals. Scientists in the UK are not allowed to culture embryos in the lab for more than 14 days for ethical reasons as gastrulation also marks the development of the nervous system. But the researchers were able to study a human embryo sample that was around 16 to 19 days of age, sourced from a woman who decided to abort her pregnancy and donate the embryo to science. Most people don’t even know they’re pregnant in the first three weeks following fertilization, which is why such embryos are so rare and challenging to study. ...
Perhaps rather surprisingly, this investigation showed that gastrulation is very similar to what mouse embryos go through. One of the notable differences is that, in human embryos, early forms of blood cells appear earlier than in mice.
Perhaps rather surprisingly, this investigation showed that gastrulation is very similar to what mouse embryos go through. One of the notable differences is that, in human embryos, early forms of blood cells appear earlier than in mice.
But, by far, the most important finding was that this particular embryo had no nervous system, unlike mice who go on to form their first neurons by week two of gestation.
This means that we now have evidence that puts into question the 14-day limit on culturing embryos, something that could have a profound impact on research and medicine in general. ..."
From the abstract:
"... Here we characterize in a spatially resolved manner the single-cell transcriptional profile of an entire gastrulating human embryo, staged to be between 16 and 19 days after fertilization. We use these data to analyse the cell types present and to make comparisons with other model systems. In addition to pluripotent epiblast, we identified primordial germ cells, red blood cells and various mesodermal and endodermal cell types. This dataset offers a unique glimpse into a central but inaccessible stage of our development. ..."
Single-cell transcriptomic characterization of a gastrulating human embryo (no public access)
Could seaweed stop coronavirus from infecting human cells?
If confirmed, this seems to be a delicious remedy! Eat more Sushi with seaweed!
The lead author of this new study Alexander Goldberg seems to be a specialist in seaweed.
The relative harmless SARS-CoV-2/Covid-19 pandemic is well under control. More than high time to return to normal life! Why SARS-CoV-2/Covid-19 is a relatively harmless disease and why the cure was worse than the disease.
"... Ulvan, the major water-soluble polysaccharide extracted from the cell wall of green seaweed, could help stop coronavirus from infecting human cells, according to a team of researchers from Tel Aviv University. ...
Through other research they knew that certain seaweed compounds had antiviral properties and so decided they wanted to evaluate them against COVID. ...
Getting started proved a challenge, Golberg recalled, mainly because they needed access to the virus, which was not readily available in Israel. He said only the Israel Institute of Biological Research had it, so they had to look outside the country. Ultimately, they partnered with a university in Alabama. ...
ulvan is effective against viruses in agriculture and also against some of the human viruses ...
They grew Ulva algae, extracted the ulvan from it and sent it to the Southern Research Institute in Alabama. There, the US team built a cellular model to assess the activity of the substance produced in Golberg’s laboratory. The cells were exposed to both the coronavirus and to ulvan. It was found that, in the presence of ulvan, the coronavirus did not infect cells. ..."
Getting started proved a challenge, Golberg recalled, mainly because they needed access to the virus, which was not readily available in Israel. He said only the Israel Institute of Biological Research had it, so they had to look outside the country. Ultimately, they partnered with a university in Alabama. ...
ulvan is effective against viruses in agriculture and also against some of the human viruses ...
They grew Ulva algae, extracted the ulvan from it and sent it to the Southern Research Institute in Alabama. There, the US team built a cellular model to assess the activity of the substance produced in Golberg’s laboratory. The cells were exposed to both the coronavirus and to ulvan. It was found that, in the presence of ulvan, the coronavirus did not infect cells. ..."
From the abstract:
"... Here we compared chemical composition and the in vitro anti- SARS-COV-2 activity of two different Ulva sp. crude ulvan extracts: one obtained by an HCl-based and another one by ammonium oxalate-based (AOx) extraction protocols. The composition of the crude extracts was analyzed and their antiviral activity was assessed in a cytopathic effect reduction assay using Vero E6 cells. We show that the extraction protocols have a significant impact on the chemical composition, anti- SARS-COV-2 activity, and cytotoxicity of these ulvan extracts. ... Our results strongly suggest that further bioassay-guided investigation into bioactivity of compounds found in Ulva sp. ulvan extracts could lead to the discovery of novel anti-SARS-CoV-2 antivirals."
The Legend Of Admiral Nelson and HMS Victory
Very recommendable! Very well narrated! The second in command kissed Nelson while he was about to die of his wounds sustained during the battle.
Saturday, December 04, 2021
The chase for nuclear fusion energy
Very recommendable! A very long and detailed article!
For about 70 years, humans have pursued the holy grail to tame nuclear fusion for peaceful energy generation! Will we finally realize it on earth? Have we reached critical mass for nuclear fusion? Nuclear fusion is the way to go!
Will the private sector and its visionary entrepreneurs once more, as so many times before in history, be a trailblazer for future energy generation? You bet! Will Big Government and the ideological dim witted elites stand in the way? Most likely!
With the practical realization of nuclear fusion energy the Global Warming hoax and the Climate Change religion will be relegated to the dustbin of history, where it undoubtedly belongs! Why are we wasting so many resources on so called Big Government energy transformation towards renewable energy etc. when nuclear fusion research etc. ought to be much better funded!
"... Long derided as a prospect that is forever 30 years away, nuclear fusion seems finally to be approaching commercial viability. There are now more than 30 private fusion firms globally, according to an October survey by the Fusion Industry Association (FIA) in Washington DC, which represents companies in the sector; the 18 firms that have declared their funding say they have attracted more than US$2.4 billion in total, almost entirely from private investments ...
The latest venture at Culham — the hub of UK fusion research for decades — is a demonstration plant for General Fusion (GF), a company based in Burnaby, Canada. It is scheduled to start operating in 2025, and the company aims to have reactors for sale in the early 2030s. It “will be the first power-plant-relevant large-scale demonstration” ...
In this respect, advocates of fusion technology say it has many parallels with the space industry. That, too, was once confined to government agencies but is now benefiting from the drive and imagination of nimble (albeit often state-assisted) private enterprise. This is “the SpaceX moment for fusion” ...
“We can smell that we’re getting close.” Investors sense the real prospect of returns on their money: Google and ... Goldman Sachs, for instance, are among those funding the fusion company TAE Technologies, based in Foothill Ranch, California, which has raised around $880 million so far. ...
This is necessarily big science, and until this century, only state-run projects could muster the resources. The scale of the enterprise is reflected today in the world’s biggest fusion effort: ITER, a fusion reactor being constructed in southern France and supported by 35 nations, including China, European Union member states, the United States, Russia, South Korea and Japan, with a price tag of at least $22 billion. ..."
The latest venture at Culham — the hub of UK fusion research for decades — is a demonstration plant for General Fusion (GF), a company based in Burnaby, Canada. It is scheduled to start operating in 2025, and the company aims to have reactors for sale in the early 2030s. It “will be the first power-plant-relevant large-scale demonstration” ...
In this respect, advocates of fusion technology say it has many parallels with the space industry. That, too, was once confined to government agencies but is now benefiting from the drive and imagination of nimble (albeit often state-assisted) private enterprise. This is “the SpaceX moment for fusion” ...
“We can smell that we’re getting close.” Investors sense the real prospect of returns on their money: Google and ... Goldman Sachs, for instance, are among those funding the fusion company TAE Technologies, based in Foothill Ranch, California, which has raised around $880 million so far. ...
This is necessarily big science, and until this century, only state-run projects could muster the resources. The scale of the enterprise is reflected today in the world’s biggest fusion effort: ITER, a fusion reactor being constructed in southern France and supported by 35 nations, including China, European Union member states, the United States, Russia, South Korea and Japan, with a price tag of at least $22 billion. ..."
Iodine ion drive propels satellite in space for the first time by ThrustMe
Good news! Brought to you by ThrustMe founded in 2017, a "tech company that designs miniature aerospace thrusters for small satellites" (Source)! 😄
"Iodine could one day propel and position constellations of mini-satellites following the first test of an iodine-based thruster in space. The system offers a cheaper, more versatile and more efficient propellant solution for manoeuvring satellites than existing electric thruster technologies, which largely rely on xenon.
‘Iodine is a game-changing propellant and our results show for the first time that it is not only a viable replacement for xenon, but that it also gives enhanced performance,’ says Trevor Lafleur, principal engineer at ThrustMe, the French company behind the technology. ..."
Frederic Tudor: The Entrepreneur Who Brought Ice to Calcutta in 1806 by Lawrence Reed
Recommendable! Another story of what free enterprise and individual liberty can achieve!
Black, Blind and Brilliant: 10 Musicians Who Overcame the Odds by Lawrence Reed
Recommendable! There were more than 10 such musicians, Mr. Reed limited himself to only ten often lesser known musicians. This is not about e.g. Ray Charles or Stevie Wonder.
Search for safer pain relief advances with new engineered compounds
Very good news! This new engineered analgesic is almost a wonder drug! Are we finally coming closer to effective pain medication without or with significantly reduced negative side effects of respiratory suppression, toleration, dependence, and addiction!
"Scientists ... have created a collection of new pain-relieving compounds that, like morphine and other drugs, provide relief via activation of opioid receptors, but without inducing many dangerous and unwanted side-effects that have driven opioid-related overdose and deaths. ...
describe a compound called SR-17018, which activates the same pain-relieving receptor as opioid drugs including morphine, oxycodone and fentanyl; however it binds to opioid receptors in a different way from those drugs, leaving the opioid receptor open and available to the body’s own natural pain-relieving substances, apparently augmenting pain relief. In a study published earlier this year ..., the group showed that the compound performed particularly well in mouse studies of chemotherapy-induced neuropathic pain, the scientists write. ...
Importantly for safety, this compound, SR-14968, proved responsive to overdose rescue medication naloxone ...
describe a compound called SR-17018, which activates the same pain-relieving receptor as opioid drugs including morphine, oxycodone and fentanyl; however it binds to opioid receptors in a different way from those drugs, leaving the opioid receptor open and available to the body’s own natural pain-relieving substances, apparently augmenting pain relief. In a study published earlier this year ..., the group showed that the compound performed particularly well in mouse studies of chemotherapy-induced neuropathic pain, the scientists write. ...
Importantly for safety, this compound, SR-14968, proved responsive to overdose rescue medication naloxone ...
the new compounds are referred to as “biased agonists,” because they activate the mu opioid receptor in a way that preferentially engages one of its signaling pathways, the one that provides pain relief, over other pathways such as those that lead to suppressed breathing.
“The compound SR-17018 is the first biased agonist of the mu opioid receptor that does not lead to tolerance with chronic use,” ...
The new compounds were engineered to avoid the “beta-arrestin” signaling cascade that leads to opioids’ dangerous and unwanted traits, including respiratory suppression, a cause of overdose, and constipation, he adds. ...
In work spanning more than two decades, ... [the] team have demonstrated the feasibility of untangling the pain-relieving properties of opioids from their negative traits. ...
The compound showed a nice, slow tapering. That, in itself, may help curb some of the dependence problems. A drug like morphine provides a quick rush then a quick clear, and you need the rush again ..."
The compound showed a nice, slow tapering. That, in itself, may help curb some of the dependence problems. A drug like morphine provides a quick rush then a quick clear, and you need the rush again ..."
Google Blogger recently started to censor my new posts
This is a very unfortunate and new development! So far two of my posts were subjected to censorship Google owned Blogger! One of the two was definitely unpublished!
I have been blogging here since 2011 and have published almost 7900 posts here!
I will monitor the situation and if this Google censorship continues and/or intensifies I will have to publish elsewhere.
Two-antibody cocktail provides broad protection against ebolaviruses
Good news! Defeating viruses one at a time!
"A combination of two highly potent antibodies, first discovered in the blood of ebolavirus survivors, protects monkeys against the three most medically important ebolavirus species, according to a new study ... The antibody “cocktail” is the first to provide such broad protection, and potentially will be a powerful weapon against future ebolavirus outbreaks. ..."
From the abstract:
"... Here, we report the development of a therapeutic cocktail comprising two broadly neutralizing human antibodies, rEBOV-515 and rEBOV-442, that recognize non-overlapping sites on the ebolavirus glycoprotein (GP). Antibodies in the cocktail exhibited synergistic neutralizing activity, resisted viral escape, and possessed differing requirements for their Fc-regions for optimal in vivo activities. The cocktail protected non-human primates from ebolavirus disease caused by EBOV, BDBV, or SUDV with high therapeutic effectiveness. ..."
Pan-ebolavirus protective therapy by two multifunctional human antibodies (no public access)
Gandhi - India's Great Soul Documentary
Very recommendable! What an extraordinary man he was!
Mahatma Gandhi in London around 1931
Ampel-Koalitionsvertrag? „Das ist ein Generalplan für die Abschaffung Deutschlands!“
Sehr empfehlenswert! Die AfD ist die einzig wählbare Partei in der Bananenrepublik Deutschland!
How NASA’s Webb Telescope Will Transform Our Place in the Universe
Recommendable! Amazing stuff! Will Webb be the stepping stone to end cosmic loneliness? 😄
Friday, December 03, 2021
Cultural Resistance: Visualizing a Nuclear-Free World - Goethe-Institut USA
Such naive and unrealistic nonsense is paid for by German taxpayers!
To advocate an end to nuclear weapons, however unrealistic this maybe, is one thing to end nuclear power is something very different! To suggest some kind of equivalence between peaceful use of nuclear power and nuclear weapons is demagoguery!
The apocalyptic belief in "nuclear peril" is outrageous being promoted by the German government!
"How do we advocate for an end to nuclear power and nuclear weapons?
Beyond research papers and speeches, articles and fact sheets, and protests on the streets, can a painter, a fashion designer, and a creative performance director convey the same urgency about our nuclear peril?"
Study reveals molecular pathway by which intense exercise promotes weight loss
Good news!
"When you try to lose weight by eating less, your body tends to resist by slowing its metabolism and ramping up the hunger pangs. This is why diets fail so often. But people who maintain long-term weight loss almost invariably exercise, and a new study from scientists at Scripps Research reveals key molecular details of this weight loss-enhancing effect. ...
engineered mice to overexpress a gene called CRCT2. This gene is among those activated by intense or new exertion, and it is known to account for many of the fitness benefits of high-intensity interval workouts.
The scientists found that by boosting CRCT2 they also could powerfully counter the metabolism-slowing, hunger-boosting effects of fasting in mice, allowing the animals to lose more weight compared to mice who lacked the extra CRCT2 activity. ..."
From the abstract:
"... Crtc2 overexpression led to greater weight loss during alternate day fasting (ADF), selective loss of fat rather than lean mass, maintenance of higher energy expenditure during the fast and reduced binge-eating during the feeding period. ..."
The Facts About COVID-19: An interview with Alex Berenson
Recommendable! A lengthy interview with the author of the new book “Pandemia: How Coronavirus Hysteria Took Over Our Government, Rights, and Lives”. For my taste, Mr. Berenson talks too verbose!
He also confirms that SARS-CoV-2/Covid-19 is a relative harmless disease, that the cure was worse than the disease and that the death toll is inflated!
"... In fact, the South Africans who’ve been treating people say it [omicron variant] appears to be as mild or milder than the delta variant or the earlier strains. And the fact is that none of the earlier strains have really been much more dangerous, including delta. There’s not a lot of evidence that their mortality was higher with delta. It’s more contagious. So the question is, is it more contagious? And the truth is, we don’t even know that either right now. ...
Lockdowns, there’s an argument about. You can argue, you can look, and you can say, “Well, if you go early enough—look at New Zealand. New Zealand did really well. They closed the country. They locked down. They didn’t have a lot of COVID.” OK. Masks there’s no argument about. Masks are useless. ...
When you try to demonstrate that standard cloth or surgical masks reduce infection, you can’t do it. And they tried last year with a big study in Denmark. It showed no efficacy of masks. That just confirmed previous studies of masks and the flu.
So they have this theory of source control that masks reduce transmission, which is effectively next to impossible to demonstrate epidemiologically.
And there’s good reason to think sort of on the biological, on the viral level, these particles [virus] are just too small for masks to do any good. ...
So, to be perfectly clear, COVID deaths probably have been overcounted. . ...
There was a small group of people who clearly didn’t die from COVID. The classic example is, yeah, the person who had COVID and got in a car accident, or the person who had COVID and died of a drug overdose. A lot of those deaths were counted as COVID.
The much bigger problem with the counting of COVID deaths ... is that most of the people who die from COVID are quite sick. They’re either extremely elderly and frail or they’re morbidly obese, or they have some other severe illness like uncontrolled diabetes, severe kidney disease. ...
And this is the thing, this is the original lie around COVID, is that we’re all at serious risk from it. That’s just not true. ...
The problem is that this illness on the whole is not serious enough to wreck society, to destroy the hospital system, or to merit the monstrous changes that we’ve made to our society in the last two years in terms of curtailing people’s freedoms, in terms of taking away school from kids for a year, in terms of now mandating that vaccine. ...
We have monstrously overreacted and the media has encouraged that rather than discouraged it. And the core way they’ve done that is to scare people who are very low risk from this, instead of saying, “Look, this is a problem and certainly, we don’t want people in nursing homes to die … we don’t want excess death of any kind, but we’re going to try to protect the people who are at risk from this to the extent we can. ...
And what I would say was “virus gonna virus,” meaning there’s just not much anybody can do. It’s an airborne respiratory virus. It’s just like the flu in that way. Virus gonna virus, and good luck trying to stop it. ..."
And this is the thing, this is the original lie around COVID, is that we’re all at serious risk from it. That’s just not true. ...
The problem is that this illness on the whole is not serious enough to wreck society, to destroy the hospital system, or to merit the monstrous changes that we’ve made to our society in the last two years in terms of curtailing people’s freedoms, in terms of taking away school from kids for a year, in terms of now mandating that vaccine. ...
We have monstrously overreacted and the media has encouraged that rather than discouraged it. And the core way they’ve done that is to scare people who are very low risk from this, instead of saying, “Look, this is a problem and certainly, we don’t want people in nursing homes to die … we don’t want excess death of any kind, but we’re going to try to protect the people who are at risk from this to the extent we can. ...
And what I would say was “virus gonna virus,” meaning there’s just not much anybody can do. It’s an airborne respiratory virus. It’s just like the flu in that way. Virus gonna virus, and good luck trying to stop it. ..."
Structure of depression-linked brain receptor solved, offering possible new treatment route for major depression
Good news! Fascinating research!
"Scientists at Scripps Research, Florida have determined the near-atomic-scale structure of an unusual brain-cell receptor called GPR158, which has been linked to depression and anxiety.
The structural study reveals both the receptor and its regulating complex, advancing understanding of basic cell receptor biology. It also enables work on potential therapeutics designed to block GPR158 as a strategy for treating depression, anxiety and possibly other mood disorders.
In the study ... the researchers used ultracold, single-particle electron microscopy, or cryo-EM, to map, at a resolution of about a third of a billionth of a meter, the atomic structure of GPR158, both on its own and when bound to a group of proteins that mediate its activity.
“We’ve been studying this receptor for more than 10 years, and have done a lot of biology on it, so it’s really gratifying to see for the first time how it’s organized,” ...
Clinical depression, also called major depressive disorder, is estimated to affect roughly 20 million people in the United States in any given year. Current treatments work on other known receptors, including monoamine, but don’t always work well for all people and alternative options are needed.
... team found in a 2018 study that GPR158 is present at unusually high levels in the prefrontal cortex of people diagnosed with major depressive disorder at the time of their death. They also found that exposing mice to chronic stress increased levels of this receptor in the mouse prefrontal cortex, leading to depression-like behavior—whereas eliminating GPR158 activity in chronically stressed mice made them resistant to depression and the effects of stress. Additionally, the activity of GPR158 receptor has been also linked to prostate cancer. ...
... team found in a 2018 study that GPR158 is present at unusually high levels in the prefrontal cortex of people diagnosed with major depressive disorder at the time of their death. They also found that exposing mice to chronic stress increased levels of this receptor in the mouse prefrontal cortex, leading to depression-like behavior—whereas eliminating GPR158 activity in chronically stressed mice made them resistant to depression and the effects of stress. Additionally, the activity of GPR158 receptor has been also linked to prostate cancer. ...
In the new study, solving the receptor’s structure offered many insights into how GPR158 works.
First, scientists found that it binds RGS complex in the same way that many receptors typically engage their conventional transducers, leading to the idea that it employs RGS proteins as means of transducing its signal.
Second, the structure revealed that the receptor exists as two interconnected copies of the GPR158 proteins stabilized by phospholipids. “These are fat-related molecules that effectively staple the two halves of the receptor together ...
First, scientists found that it binds RGS complex in the same way that many receptors typically engage their conventional transducers, leading to the idea that it employs RGS proteins as means of transducing its signal.
Second, the structure revealed that the receptor exists as two interconnected copies of the GPR158 proteins stabilized by phospholipids. “These are fat-related molecules that effectively staple the two halves of the receptor together ...
Finally, on the other side of the receptor that faces outside of the cell, an unusual module called the cache domain was revealed. The authors believe the cache domain serves as a trap for the molecules that activate GPR158. Cache domains have never been observed in these types of receptors before, demonstrating the unique biology of this orphan receptor. ..."
From the abstract:
"GPR158 is an orphan G-protein-coupled receptor (GPCR) highly expressed in the brain where it controls synapse formation and function. GPR158 has also been implicated in depression, carcinogenesis and cognition. However, the structural organization and signaling mechanisms of GPR158 are largely unknown. Here, we report structures of the human GPR158 alone and bound to an RGS signaling complex, determined using single-particle cryo-electron microscopy (cryoEM). The structures reveal a homodimeric organization stabilized by a pair of phospholipids and the presence of an extracellular Cache domain, an unusual ligand-binding domain in GPCRs.-. We further demonstrate the structural basis of GPR158 coupling to RGS7-Gβ5. Together, these results provide insights into the unusual biology of orphan receptors and the formation of GPCR-RGS complexes."
New advance in modeling the chemistry of the origin of life
Amazing stuff!
"... In a study reported in the chemistry journal Angewandte Chemie, the scientists demonstrated a set of related reactions that could have enabled the transition, on the primordial Earth, from pre-life chemistry to the biochemistry of the first simple life forms. The reactions yield molecular building blocks that can be stitched into DNA-like strands, either with the help of reaction-speeding organic catalyst molecules that were plausibly present before life arose, or with more efficient enzyme catalysts that early life forms would have used. ..."
From the abstract:
"Polymerization of nucleic acids in biology utilizes 5′-nucleoside triphosphates (NTPs) as substrates. The prebiotic availability of NTPs has been unresolved and other derivatives of nucleoside-monophosphates (NMPs) have been studied. However, this latter approach necessitates a change in chemistries when transitioning to biology. Herein we show that diamidophosphate (DAP), in a one-pot amidophosphorylation-hydrolysis setting converts NMPs into the corresponding NTPs via 5′-nucleoside amidophosphates (NaPs). The resulting crude mixture of NTPs are accepted by proteinaceous- and ribozyme-polymerases as substrates for nucleic acid polymerization. This phosphorylation also operates at the level of oligonucleotides enabling ribozyme-mediated ligation. This one-pot protocol for simultaneous generation of NaPs and NTPs suggests that the transition from prebiotic-phosphorylation and oligomerization to an enzymatic processive-polymerization can be more continuous than previously anticipated."
Stunning waste: Unemployment fraud during COVID cost more than triple total benefits paid in 2019
This is usually what you get when government turns on the spigot of spending or largesse! Don't think that e.g. Build Back Better is any better (pardon my pun)!
"Unemployment fraud exploded during the COVID-19 pandemic, according to the U.S. Labor Department Inspector General's semiannual report to Congress.
Approximately $872 billion in federal funding was allocated to unemployment benefits in the last year, and at least 10% was estimated to be paid "improperly, with a significant portion attributable to fraud." ...
More than 27,000 complaints and investigations related to unemployment benefits paid have been opened by the inspector general. The office is reviewing an additional 132,000 complaints from the National Center for Disaster Fraud. These investigations now account for 92% of the government watchdog's cases. Before COVID, only 12% of the cases involved unemployment fraud."
More than 27,000 complaints and investigations related to unemployment benefits paid have been opened by the inspector general. The office is reviewing an additional 132,000 complaints from the National Center for Disaster Fraud. These investigations now account for 92% of the government watchdog's cases. Before COVID, only 12% of the cases involved unemployment fraud."
U.S. Secretary of Defense Austin makes 'Soviet Union' gaffe on official visit in South Korea
Maybe the 46th President is not the only demented and senile person in the administration!
"... U.S. Secretary of Defense Lloyd Austin, who said in a Thursday press briefing that he hopes the Soviet Union will not soon invade Ukraine. ..."
His transcripted words: "The best case, though, is that we won't see an incursion by the Soviet Union into Ukraine."
How India Became the New Hope for Tech Investors
Recommendable! A sleeping giant wakes up! Note how many women are involved!
Thursday, December 02, 2021
Google project Relate: A communication tool for people with speech impairments
Very commendable! Bravo Google! Probably, many of us have weekly or even daily experience talking to someone with such an impairment.
"For millions of people, being able to speak and be understood can be difficult as a result of conditions that can impact speech, including stroke, ALS, Cerebral Palsy, traumatic brain injury or Parkinson's disease. Today, we’re inviting an initial group of people to test Project Relate, a new Android app that aims to help people with speech impairments communicate more easily with others and interact with the Google Assistant. ..."
Credits: Andrew Ng's weekly The Batch newsletter
The China Initiative, US crackdown on Chinese economic espionage, is a mess. We have the data to show it
This seems to be a very dubious article by MIT Technology Review!
Did the so called "mess" start or continue with the 46th President? Quite possible!
"... China Initiative, an effort to counter rising concerns about Chinese economic espionage and threats to US national security. Started in 2018, the initiative was a centerpiece of the Trump administration’s hardening stance against China. ..."
Trump Derangement Syndrome might be the primary motivation behind this article!
"The initiative was supposed to focus on economic espionage, but it has increasingly charged academics with "research integrity" issues."
What a nonsense! First, it is not exclusively about economic, but also about technological espionage! A Chinese professor or student could be a spy! It is often academic research that translates into new technologies, so spying at universities makes perfect sense for the Communist Party of China.
"Nearly 90% of the defendants charged are of Chinese heritage."
So what? Accusation of xenophobia? After all this investigation is about Chinese espionage to gain an advantage!
"... Today, after months of research and investigation, MIT Technology Review is publishing a searchable database of 77 cases and more than 150 defendants. While likely incomplete, the database represents the most comprehensive accounting of the China Initiative prosecutions to date. ...
Only about a quarter [???] of people and institutions charged under the China Initiative have been convicted. ...
Many cases [???] have little or no obvious connection to national security or the theft of trade secrets. ..."
Only about a quarter [???] of people and institutions charged under the China Initiative have been convicted. ...
Many cases [???] have little or no obvious connection to national security or the theft of trade secrets. ..."
Only a quarter??? 25% is a lot in such a short time!!!
Virtual Try-On: Sizer Transforms The Digital Shopping Experience
Not bad! Good for online shopping!
"... For consumers that use the patented body measurement app from Herzliya-based startup Sizer Technologies, AI has become a way to generate accurate clothing sizes without going into the store. The company’s AI tech and deep learning algorithms calculate a customer’s precise body measurements in a single one-time scan. The app uses the front-end camera of any mobile device for personalized true sizing data that is tailored to the individual’s fit. ..."
The absurd arguments of Justice Sotomayor regarding abortion
Justice Sonia Sotomayor in her oral arguments on 12/1/2021 in No. 19-1392 said some highly controversial things. You may wonder whether her most outstanding qualification to become a justice of the highest court of the land in 2009 was, because she is a Latina!
She based her argument on brain death??? Bizarre!
She appears to connect brain death and the consciousness of a fetus with brain death??? Bizarre! What a brain dead argument!
Is she perhaps implying that because consciousness of a human does not begin before about 24-28th week of gestation that a fetus can be aborted, because it is like a brain death person? Do we even know for sure that human consciousness begins so late? I seriously doubt it!
She also implied that abortion was OK, because the viability of a fetus does not start before 23-24 weeks. So absurd, so inhumane!
She is also pretty stupid when she argues that changing Roe v. Wade would be seen as a mere political act. Was not Roe v. Wade perhaps a political act itself thanks to the composition of justices back then and the prevailing political trends of that time?
Justice Sotomayor: "Virtually every state defines a brain death as death. Yet, the Official - Subject to Final Review literature is filled with episodes of people who are completely and utterly brain dead responding to stimuli. There's about 40 percent of dead people who, if you touch their feet, the foot will recoil. There are spontaneous acts by dead brain people. So I don't think that a response to -- by a fetus necessarily proves that there's a sensation of pain or that there's consciousness."
Justice Sotomayor: "So I go back to my question of, what has changed in science to show that the viability line is not a real line, that a fetus cannot survive? And I think that's what both courts below said, that you had no expert say that there is any viability before 23 to 24 weeks"
Justice Sotomayor: "Now the sponsors of this bill, the House bill, in Mississippi, said we're doing it because we have new justices. The newest ban that Mississippi has put in place, the six-week ban, the Senate sponsor said we're doing it because we have new justices on the Supreme Court. Will this institution survive the stench that this creates in the public perception that the Constitution and its reading are just political acts?"
Physicians Say Hospitals Are Pressuring ER Docs to List COVID-19 on Death Certificates
I have blogged here multiple times that I think the death toll is inflated! The case number is possibly inflated as well not least due to dubious test results.
Mark Twain: “Figures often beguile me, particularly when I have the arranging of them myself; in which case the remark attributed to Disraeli would often apply with justice and force: 'There are three kinds of lies: lies, damned lies, and statistics’”. (Source)
"During their long discussion with reporters, Dr. Erickson noted he has spoken to numerous physicians who say they are being pressured to add COVID-19 to death certificates and diagnostic lists—even when the novel coronavirus appears to have no relation to the victim’s cause of death. ...
Earlier this month, Illinois’s top health official explained that any victim diagnosed with the novel coronavirus would be classified as a COVID-19 death—regardless of whether it contributed to the patient’s death. ...
who was applying the alleged pressure on physicians, he said it was hospital administration. ...
hospitals are incentivized to pressure physicians to include COVID-19 on death certificates and discharge papers, since the CARES Act increases Medicare payments to hospitals treating COVID-19 victims. ..."
Morbidly Obese Man Loses 160lb for Newborn Son: ‘If You’re 406lb, You Need a Life Change’
That is a worthy excuse to get rid of lots of excessive pounds! I remember my father gave up his smoking habit when I was born, he was a heavy chain smoker.
In Ghana for ‘spiritual cleansing,’ NYC Mayor-elect Eric Adams celebrates Hanukkah with Chabad
This is a bit of unusual news!
"Eric Adams told reporters he planned to engage in “some spiritual cleansing” during a trip to Ghana this week. Still, the appearance of New York City’s mayor-elect at a Hanukkah party Wednesday in Accra came as a surprise.
Adams joined Rabbi Noach Majesky, a Brooklyn expat who is Chabad’s emissary in Ghana, onstage for an event to celebrate the fourth night of Hanukkah ..."
AfD: Wir sind klar GEGEN die IMPF-PFLICHT und zum neuesten Bundesverfassungsgerichts Urteils
Sehr empfehlenswert! Das BVerfG, ein Büttel der Regierung! Die AfD ist die einzig wählbare Partei in der Bananenrepublik! Sie hat die FDP weit hinter sich gelassen!
The Difference Between Judaism & Other Religions
Is mass revelation! I did not know that. What a revelation! Many other major religions are based one one individual receiving and/or providing the revelation like Islam, Christianity, Buddhism ...
On the flip side, because of the mass revelation, Jews believe or a seen to be the chosen people, which is one, but not the only reason they have been made a unjustified target by others throughout history.
Wednesday, December 01, 2021
Hunter Biden in center of geopolitical movements which were negative for US interest with Miranda Devine
Very recommendable! About the corrupt Biden clan! The 46th President is most likely seriously compromised as far as Russia and China is concerned!
Freedom in the 50 States of America 2021 Edition
Recommendable! An important compendium!
New Hampshire (Motto: "Live free or die") is no. 1!
Nevada (Unofficial motto: "What happens in Nevada, stays in Nevada" 😉) is no. 3
Prehistoric Iberians poisoned by cinnabar (mercury) almost 5000 years ago
A case of "the life of man, solitary, poor, nasty, brutish, and short" (Hobbes Leviathan, source) as far as the life of our ancestors is concerned?
"Traces of the earliest-known cases of mercury poisoning, dating back almost 5000 years, have been discovered in ancient tombs in Spain and Portugal. They’re thought to have been caused by the extensive use of cinnabar – mercury sulfide – as a bright red pigment in prehistoric times.
Analysis of human bones from more than 50 tombs across the Iberian peninsula revealed very high levels of mercury poisoning in people buried during the Copper Age, between about 2900BC and 2600BC ..."
Kinematic self-replication in reconfigurable organisms
Recommendable! The title of this research work sounds cryptic, but it may be a game changer.
"Almost all organisms replicate by growing and then shedding offspring. Some molecules also replicate, but by moving rather than growing: They find and combine building blocks into self-copies. Here we show that clusters of cells, if freed from a developing organism, can similarly find and combine loose cells into clusters that look and move like they do, and that this ability does not have to be specifically evolved or introduced by genetic manipulation. Finally, we show that artificial intelligence can design clusters that replicate better, and perform useful work as they do so. This suggests that future technologies may, with little outside guidance, become more useful as they spread, and that life harbors surprising behaviors just below the surface, waiting to be uncovered."
From the abstract:
"All living systems perpetuate themselves via growth in or on the body, followed by splitting, budding, or birth. We find that synthetic multicellular assemblies can also replicate kinematically by moving and compressing dissociated cells in their environment into functional self-copies. This form of perpetuation, previously unseen in any organism, arises spontaneously over days rather than evolving over millennia. We also show how artificial intelligence methods can design assemblies that postpone loss of replicative ability and perform useful work as a side effect of replication. This suggests other unique and useful phenotypes can be rapidly reached from wild-type organisms without selection or genetic engineering, thereby broadening our understanding of the conditions under which replication arises, phenotypic plasticity, and how useful replicative machines may be realized."
New tool predicts where coronavirus binds to human proteins
Good news!
See also why the Covid-19 is a relative harmless disease!
"A computational tool allows researchers to precisely predict locations on the surfaces of human and COVID-19 viral proteins that bind with each other, a breakthrough that will greatly benefit our understanding of the virus and the development of drugs that block binding sites. ...
The study ... describes the tool and uses it to predict how the SARS-COV-2 diverged structurally from SARS-COV-1 (which caused a SARS outbreak in 2002-04); how genetic variation of proteins in human populations may contribute to virus-human binding and higher risk of infection; and which existing drugs show promise for binding to targets on surfaces of human proteins. ..."
The study ... describes the tool and uses it to predict how the SARS-COV-2 diverged structurally from SARS-COV-1 (which caused a SARS outbreak in 2002-04); how genetic variation of proteins in human populations may contribute to virus-human binding and higher risk of infection; and which existing drugs show promise for binding to targets on surfaces of human proteins. ..."
From the abstract:
"... To facilitate broader exploration of how pathogen–host interactions might impact transmission and virulence in the ongoing COVID-19 pandemic, we performed state-of-the-art interface prediction followed by molecular docking to construct a three-dimensional structural interactome between SARS-CoV-2 and human. We additionally carried out downstream meta-analyses to investigate enrichment of sequence divergence between SARS-CoV-1 and SARS-CoV-2 or human population variants along viral–human protein-interaction interfaces, predict changes in binding affinity by these mutations/variants and further prioritize drug repurposing candidates predicted to competitively bind human targets. ..."
Milestone: Over 8 billion doses of Covid-19 vaccine administered worldwide
According to Johns Hopkins University Resource Center we have reached this milestone on 12/1/2021. Contrast this with total world population of about 7.9 billion.
About every 30 days, 1 billion doses of the vaccine are administered! Absolutely mind boggling!
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