Saturday, December 04, 2021

Two-antibody cocktail provides broad protection against ebolaviruses

Good news! Defeating viruses one at a time!

"A combination of two highly potent antibodies, first discovered in the blood of ebolavirus survivors, protects monkeys against the three most medically important ebolavirus species, according to a new study ... The antibody “cocktail” is the first to provide such broad protection, and potentially will be a powerful weapon against future ebolavirus outbreaks. ..."

From the abstract:
"... Here, we report the development of a therapeutic cocktail comprising two broadly neutralizing human antibodies, rEBOV-515 and rEBOV-442, that recognize non-overlapping sites on the ebolavirus glycoprotein (GP). Antibodies in the cocktail exhibited synergistic neutralizing activity, resisted viral escape, and possessed differing requirements for their Fc-regions for optimal in vivo activities. The cocktail protected non-human primates from ebolavirus disease caused by EBOV, BDBV, or SUDV with high therapeutic effectiveness. ..."

Two-antibody cocktail provides broad protection against ebolaviruses | Scripps Research

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