This could be an interesting review article (unfortunately no public access)!
"Oxidized lipids—fats structurally altered by enzymes, oxygen or free radicals—are double-edged swords that can both quell and ignite systemic inflammation, according to a new comprehensive review aimed at sharpening the overall understanding of an intricate class of highly reactive molecules. ...
The research joins a growing body of analyses that have zeroed in on the impact of oxidized lipids in disorders marked by chronic inflammation. Lipids undergoing enzymatic or nonenzymatic oxidation play critical roles in regulating inflammation ...
Historically, oxPLs were viewed merely as benign byproducts of oxidative stress. But, as the two scientists underscore, oxPLs are now regarded as potent, bioactive molecules that can bind to specific receptors on immune cells, triggering intracellular signaling pathways.
This, in turn, disrupts cellular homeostasis, promotes chronic inflammation and actively drives the progression of various physiological conditions, such as aging, and—of greater concern—certain life-threatening disease processes. ..."
From the abstract:
"Host-derived lipids undergoing enzymatic or nonenzymatic oxidation play critical roles in regulating inflammation.
Polyunsaturated fatty acids, cholesterol, and cholesterol intermediates can be enzymatically oxidized and serve as signaling mediators controlling tissue homeostasis and immunity.
Spontaneously generated oxidized lipids, including nonenzymatically oxidized phospholipids (oxPLs), result from oxidative stress and accumulate during inflammation, affecting cellular metabolism, immune cell functions, and cell fate. These distinct classes of oxidized lipids not only share overlapping inflammatory roles but also exhibit divergent effects depending on their molecular structures and cellular targets.
This Review highlights the double-edged nature of oxPLs: Although their transient production triggers protective responses, their accumulation sustains inflammation, contributing to tissue damage.
We also discuss the emerging roles of oxPLs in cell death programs, immune cell activation, and stromal cell functions, which are critical processes favoring tumor growth. Overall, we highlight how oxidized lipids orchestrate immune responses and explore their contribution to infectious diseases and cancer."
Regulation of inflammation by oxidized lipids (review article, no public access)
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