Gastric cancer and other cancers biomarker nearly 90% accurate, even in early stages

Good news! Cancer is history (soon)!

"Researchers have identified a blood protein that can be used as a marker of gastric and other cancers and is more accurate than existing diagnostic biomarkers, even in the early stages of the disease. The simple test may lead to the earlier diagnosis of often stealthy gastrointestinal cancers. ...

They found that stromal cell-derived factor 4 (SDF4) was a potential serum diagnostic tumor marker.

They collected blood samples from 582 patients with gastric, breast, colorectal, pancreatic, esophageal and liver cancer, and 80 healthy controls, and found that SDF4 was consistently elevated in the cancer samples. ..."

"... As simple blood tests accurately detect the protein, their findings suggest the potential of the marker in the early detection of gastric cancer. ..."

From the abstract:

"There is a need for serum diagnostic biomarkers to improve the prognosis of solid malignant tumors. Here, we conducted a single-institutional study to evaluate the diagnostic performance of serum stromal cell-derived factor 4 (SDF4) levels in cancer patients. Serum samples were collected from a total of 582 patients with solid cancers including gastric cancer (GC) and 80 healthy volunteers. SDF4 protein levels in sera, and conditioned media or lysates of human GC cell lines were measured by enzyme-linked immunosorbent assay, and those in GC tissue by immunohistochemistry. Serum SDF4 levels were higher in patients with cancer than the healthy control in all cancer type. Regarding GC, serum SDF4 levels distinguished healthy controls from GC patients with the area under the curve value of 0.973, sensitivity of 89%, and specificity of 99%. Serum SDF4 levels were significantly elevated in patient with early stage GC. In immunohistochemistry, the frequency of SDF4-positive GC tumors did not vary significantly between GC stages. The ability of human GC cell lines to both produce and secrete SDF4 was confirmed in vitro. In conclusion, serum SDF4 levels could be a promising candidate for a novel diagnostic biomarker for GC and other malignancies."

Gastric cancer biomarker nearly 90% accurate, even in early stages

Tumor marker detects gastric cancer with nearly 90% accuracy

Identification of stromal cell-derived factor 4 as a liquid biopsy-based diagnostic marker in solid cancers (open access)

Figure 4 (a) Representative immunohistochemical staining of SDF4 in normal gastric and GC tissues. ... (b) Proportion of tumors at each stage staining positively for SDF4.