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"... Incredibly, a new study now suggests up to half of inherited ADHD can be explained by single gene variations, instead of clusters of different genes contributing together, as previously suspected. ...
So [researchers] examined the entire genomes of 77 US children with ADHD and their families' to discover the surprising clue to why this might be the case. ...
Similar rates of single gene variations have also been observed in autism, which has been associated with atypical methylation too. ..."
From the abstract:
"Genomic research on attention-deficit/hyperactivity disorder (ADHD) previously focused on common variants; however, polygenic heritability (28%) is lower than phenotypic heritability (76%) for ADHD, and genome-wide association studies revealed increased burden of rare copy-number variations and missense and disruptive variants to constrained genes in pediatric ADHD. Available genomic repositories for ADHD contain heterogeneous clinical phenotypes. Consequently, identification of genetic mechanisms specific to ADHD has been challenging. This study assessed monogenic contributions to pediatric ADHD in a well-characterized familial cohort."
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