Amazing stuff! Good news!
"... After damaging their kidneys to simulate kidney disease, the scientists found that the spiny mice not only regenerated the structure and function of nephrons, the tiny filters that make up the kidney, but they did so without the dangerous scarring that normally occurs in mammals. ...
“We used the term ‘functional regeneration’ because spiny mice sustain severe kidney injury initially but then completely restore kidney function within two weeks. This differs from many kinds of ‘repair’ responses, including fibrotic repair, that restore tissue continuity but do so with variable degrees of loss of organ function,” ..."
“We used the term ‘functional regeneration’ because spiny mice sustain severe kidney injury initially but then completely restore kidney function within two weeks. This differs from many kinds of ‘repair’ responses, including fibrotic repair, that restore tissue continuity but do so with variable degrees of loss of organ function,” ..."
From the abstract:
"Fibrosis-driven solid organ failure is an enormous burden on global health. Spiny mice (Acomys) are terrestrial mammals that can regenerate severe skin wounds without scars to avoid predation. ... Here, we show that despite equivalent acute obstructive or ischemic kidney injury, spiny mice fully regenerate nephron structure and organ function without fibrosis, whereas C57Bl/6 or CD1 mice progress to complete organ failure with extensive renal fibrosis. Two mechanisms for vertebrate regeneration have been proposed that emphasize either extrinsic (pro-regenerative macrophages) or intrinsic (surviving cells of the organ itself) controls. Comparative transcriptome analysis revealed that the Acomys genome appears poised at the time of injury to initiate regeneration by surviving kidney cells, whereas macrophage accumulation was not detected until about day 7. Thus, we provide evidence for rapid activation of a gene expression signature for regenerative wound healing in the spiny mouse kidney."
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