Sunday, November 28, 2021

Poop transplant rejuvenates brain of old mice

Amazing stuff! It has been reported multiple times over the past decades that fecal  transplants can be beneficial to health. Here is another research result confirming this!

"... transplanted the poop of 3 to 4-month-old mice into the intestines of 19- to 20-month-old mice. The age difference is equivalent to that between 18-year-old and 70-year-old humans.
After some time, the transplanted fecal bacteria colonized the guts of the elderly rodents, growing and expanding until the microflora of the young and old mice resembled each other. ...
that the results can be explained by the altered rejuvenated microbiome, with research over the past decade showing it plays a major role in brain function. Previously, Cryan’s team showed that introducing a specific strain of Lactobacillus bacteria into the guts of mice reduces levels of the stress hormone corticosterone and reduces anxiety and depression.
The effects of the poop transplant could also be seen in the brain’s physiology. When the researchers examined the brains of older mice they found that the hippocampus — a region of the brain associated with forming and storing memories — resembled that of young mice. Essentially, the fecal transplant helped reverse neurodegenerative effects in the brain. ..."

From the abstract:
"The gut microbiota is increasingly recognized as an important regulator of host immunity and brain health. The aging process yields dramatic alterations in the microbiota, which is linked to poorer health and frailty in elderly populations. However, there is limited evidence for a mechanistic role of the gut microbiota in brain health and neuroimmunity during aging processes. Therefore, we conducted fecal microbiota transplantation from either young (3–4 months) or old (19–20 months) donor mice into aged recipient mice (19–20 months). Transplant of a microbiota from young donors reversed aging-associated differences in peripheral and brain immunity, as well as the hippocampal metabolome and transcriptome of aging recipient mice. Finally, the young donor-derived microbiota attenuated selective age-associated impairments in cognitive behavior when transplanted into an aged host. ..."

Poop transplant rejuvenates brain of old mice

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