What changes happen in the aging brain? A comprehensive single-cell atlas to date of epigenetic changes in the aging mouse brain

Very impressive!

"Highlights

• Salk researchers create epigenetic atlas of cell type-specific changes in the aging mouse brain
• The atlas represents eight different brain regions and 36 different cell types, and shows clear epigenetic differences associated with different ages
• The new resource—available publicly on Amazon Web services—can be used to unravel age-related contributions to neurodegenerative diseases like Alzheimer’s, Parkinson’s, and ALS

...

One major mechanistic influence on aging is epigenetic change: the way small chemical tags on top of our base genetic code shift over time to alter gene expression. Salk researchers created the most comprehensive single-cell atlas to date of epigenetic changes in the aging mouse brain, revealing how DNA methylation, genome structure, and gene activity change across brain regions and cell types. The new atlas represents eight brain regions and 36 distinct brain cell types, with over 200,000 single cells profiled across methylation and chromatin conformation assays, plus nearly 900,000 cells captured with spatial transcriptomics. ..."

What changes happen in the aging brain? - Salk Institute for Biological Studies "Salk Institute scientists create atlas of cell type-specific epigenetic changes that occur in the mouse brain as it ages to better understand the basis of neurodegenerative diseases"

Salk researchers used spatial transcriptomics to map where different cell types reside in the mouse brain. Shown are excitatory neurons (left, blue), inhibitory neurons (middle, red), and non-neuronal cells (right, green), color-coded by cell type.