Recommendable! Is this finally the breakthrough many men and some women have been waiting for for many decades if not centuries and longer! There appear to be some serious caveats with this study.
"There's promising new research to report in efforts to reverse baldness: A new study shows how restorative hair growth can be triggered in mice within 20 days, by stimulating fat cells around hair follicles in the skin.
Led by researchers from the National Taiwan University, the study builds on established knowledge of how skin irritation and injury often trigger hair growth. ...
There's a key caveat: The treatment is only effective on hair follicles that are in a resting stage – waiting for the signal to grow again. On the human scalp, baldness typically shifts the lengths of these stages hair by hair – it's more complex than shaving the hair off, as was done with the mice. ..."
From the highlights and abstract:
"Highlights
• Skin injury triggers rapid adipocyte lipolysis through skin inflammation
• Macrophage-adipocyte interaction stimulates adipocyte lipolysis through SAA3
• MUFAs stimulate quiescent eHFSCs via Pgc1-α, which boosts mitochondrial functions
• Topical treatment of MUFAs promotes hair growth by activating eHFSCs
Summary
Adipocytes as vital energy reservoirs respond to systemic metabolic demands by storing or releasing lipids. Whether they can promote tissue regeneration through local metabolic communication remains unclear.
We found that after skin injury, macrophages quickly infiltrate dermal adipose tissue, where they promote free fatty acid release from adipocytes via serum amyloid A3-dependent lipolysis, which, in turn, promotes hair regrowth. Epithelial hair follicle stem cells (eHFSCs) absorb the released monounsaturated fatty acids via fatty acid translocase CD36 and activate the transcriptional coactivator Pgc1-α. Downstream of Pgc1-α, increased fatty acid oxidation and mitochondrial biogenesis enhance energy production, enabling eHFSCs to exit quiescence.
Topical treatment of monounsaturated fatty acids suffices to promote hair growth by activating eHFSCs.
Our findings demonstrate a macrophage-to-adipocyte-to-hair follicle axis that promotes tissue-level regeneration via short-range metabolic signaling through free fatty acids.
Analogous regeneration-facilitating mechanisms elicited by injury-induced panniculitis may operate in other adipose-rich organs."
Adipocyte lipolysis activates epithelial stem cells for hair regeneration through fatty acid metabolic signaling
Credits: The Flyover
Graphical abstract
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