Good news!
"A likely cause of loss of vitality in aging is the reduced restorative capacity of stem cells. Lei et al. examined the potential of transplanted human mesenchymal progenitor cells (MPCs) to slow aging. The authors transplanted human MPCs into aged macaque monkeys.
They used normal MPCs or cells that expressed an engineered version of the FOXO3 transcription factor designed to enhance their resistance to aging. These therapies promoted measurable improvement in some cognitive measures, and reproductive cells showed profiles characteristic of younger animals. The results support the potential of such stem cells, particularly the engineered ones and contents of exosomes derived from them, to help delay or even partially reverse some characteristics of aging."
From the highlights and abstract:
"Highlights
• Genetically enhanced senescence-resistant cells exhibit anti-aging effects
• These SRCs counteract systemic aging in primates
• SRCs boost cognitive and reproductive rejuvenation
• SRCs deliver geroprotection through exosomal cargoes
Summary
Aging is characterized by a deterioration of stem cell function, but the feasibility of replenishing these cells to counteract aging remains poorly defined.
Our study addresses this gap by developing senescence (seno)-resistant human mesenchymal progenitor cells (SRCs), genetically fortified to enhance cellular resilience.
In a 44-week trial, we intravenously delivered SRCs to aged macaques, noting a systemic reduction in aging indicators, such as cellular senescence, chronic inflammation, and tissue degeneration, without any detected adverse effects. Notably, SRC treatment enhanced brain architecture and cognitive function and alleviated the reproductive system decline.
The restorative effects of SRCs are partly attributed to their exosomes, which combat cellular senescence.
This study provides initial evidence that genetically modified human mesenchymal progenitors can slow primate aging, highlighting the therapeutic potential of regenerative approaches in combating age-related health decline."
Senescence-resistant human mesenchymal progenitor cells counter aging in primates (no public access)
Graphical abstract
No comments:
Post a Comment