Good news! Cancer is history (soon)!
"A bacterium in the gut microbiome can boost the effects of cancer drugs, called immune checkpoint inhibitors, in mice. The microbe, Hominenteromicrobium mulieris, stimulates immune cells that go on to amplify the effects of checkpoint inhibitors, unleashing the mice’s own defences against tumours. Checkpoint inhibitors can be potent cancer-killers, but don’t work for everyone who receives them. Researchers are now planning a clinical trial to test whether H. mulieris has a drug-boosting effect in people."
From the abstract:
"Gut microbiota influence the antitumour efficacy of immune checkpoint blockade, but the mechanisms of action have not been fully elucidated.
Here, we show that a new strain of the bacterial genus Hominenteromicrobium (designated YB328) isolated from the faeces of patients who responded to programmed cell death 1 (PD-1) blockade augmented antitumour responses in mice.
YB328 activated tumour-specific CD8+ T cells through the stimulation of CD103+CD11b− conventional dendritic cells (cDCs), which, following exposure in the gut, migrated to the tumour microenvironment.
Mice showed improved antitumour efficacy of PD-1 blockade when treated with faecal transplants from non-responder patients supplemented with YB238.
This result suggests that YB328 could function in a dominant manner.
YB328-activated CD103+CD11b− cDCs showed prolonged engagement with tumour-specific CD8+ T cells and promoted PD-1 expression in these cells. Moreover, YB238-augmented antitumour efficacy of PD-1 blockade treatment was observed in multiple mouse models of cancer. Patients with elevated YB328 abundance had increased infiltration of CD103+CD11b− cDCs in tumours and had a favourable response to PD-1 blockade therapy in various cancer types.
We propose that gut microbiota enhance antitumour immunity by accelerating the maturation and migration of CD103+CD11b− cDCs to increase the number of CD8+ T cells that respond to diverse tumour antigens."
Found: a human gut microbe that makes cancer therapy more effective in mice (no public access) "Cancer therapies called checkpoint inhibitor drugs, which ratchet up the immune system, work better when this bacterium is around."
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