Good news! Cancer is history (soon)!
With this kind of advice one will die of starvation and suffer mental and physical decline first! A case of junk science or quackery? This seems to be definitely a case junk science journalism to claim 24 hours fasting twice a weak! Click bait!
From the highlights and abstract:
"Highlights
• Cyclic fasting promotes NK cell-mediated anti-tumor immunity
• Cyclic fasting promotes metabolic reprogramming of splenic NK cells
• Fasting-induced fatty acid oxidation improves the NK cell anti-tumor response
• Cyclic fasting redistributes NK cells to the bone marrow, where they are primed by IL-12
Summary
Fasting is associated with improved outcomes in cancer. Here, we investigated the impact of fasting on natural killer (NK) cell anti-tumor immunity. Cyclic fasting improved immunity against solid and metastatic tumors in an NK cell-dependent manner. During fasting, NK cells underwent redistribution from peripheral tissues to the bone marrow (BM). In humans, fasting also reduced circulating NK cell numbers. NK cells in the spleen of fasted mice were metabolically rewired by elevated concentrations of fatty acids and glucocorticoids, augmenting fatty acid metabolism via increased expression of the enzyme CPT1A, and Cpt1a deletion impaired NK cell survival and function in this setting. In parallel, redistribution of NK cells to the BM during fasting required the trafficking mediators S1PR5 and CXCR4. These cells were primed by an increased pool of interleukin (IL)-12-expressing BM myeloid cells, which improved IFN-γ production. Our findings identify a link between dietary restriction and optimized innate immune responses, with the potential to enhance immunotherapy strategies."
Fasting reshapes tissue-specific niches to improve NK cell-mediated anti-tumor immunity (no public access)
Graphical abstract
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