Women's heart attacks differ from men's, this gene may be why - study

Any transgender biological male ought to read this article and the study! 😄

Beware: The study must be racist and contains colonialism. All subjects had "European ancestry" (Caution: Satire)

"... Heart attacks and heart disease in women are often overlooked by medical workers, and while the reasons behind this have often been debated, a newly identified gene may have the answer, according to a new study. ...

Overall, men suffer from heart attacks and IHD-induced deaths at earlier ages than women. But IHD mortality rates among women sharply spike ahead of men after age 65. After contracting MI, over a third (35%) of women have another heart attack within just six years – which is double what occurs in men. ..."

From the abstract:

"Background

Ischemic coronary heart disease (IHD) is the leading cause of death worldwide. Genetic variation is presumed to be a major factor underlying sex differences for IHD events, including mortality. The purpose of this study was to identify sex-specific candidate genes associated with all-cause mortality among people diagnosed with coronary artery disease (CAD).

Methods

We performed a sex-stratified, exploratory genome-wide association (GWAS) screen using existing data from CAD-diagnosed males (n = 510) and females (n = 174) who reported European ancestry from the Duke Catheterization Genetics biorepository. ...

Results

The top GWAS hits associated with all-cause mortality among people with CAD included 8 SNPs among males and 15 among females (p = 1 × 10−6 or 10−7), adjusted for covariates. Cross-sex comparisons revealed distinct candidate genes. ...

Conclusions

We report 20 sex-specific candidate genes having suggestive association with all-cause mortality among CAD-diagnosed subjects. Findings demonstrate proof of principle for identifying sex-associated genetic factors that may help explain differential mortality risk in people with CAD. ..."

Women's heart attacks differ from men's, this gene may be why - study - The Jerusalem Post Heart disease kills more people worldwide than any other disease, but it often goes undiagnosed in women, who are more likely to die of it than men. This gene may be why.

Sex-dimorphic gene effects on survival outcomes in people with coronary artery disease (open access)

Fig. 3. Venn diagram of top candidate genes and shared genetic variation, by sex. Genes in bold have biological relevance to cardiovascular disease or survival. †Top male SNP that also shows p < .05 among females (does not appear in list of top candidates for females).