Is here the AAAS suggesting that older men can benefit from castration?
Is this research part of or in support of LGBTQ ideology? Ask the researchers involved in this study!
This study also confirms the well and very long known effect of feminization in eunuchs.
"Studies have found that removing the testicles extends male life span across many mammalian species, including humans. But a research team exploring this effect has now found the surgical procedure doesn’t have to be performed early in life to boost longevity, as scientists had assumed, upending prevailing ideas of how the testes influence aging. ...
However, the oldest mice that were neutered gained the most: The procedure stretched their lives by about 33%, compared with 19% and 26% increases, respectively, for the animals fixed before or after puberty. In fact, none of the older mice died for more than a year after the procedure. ..."
From the abstract:
"Men live shorter lives than women across nearly all human populations, a disadvantage that extends across most biological causes of death and that cannot be fully explained by behavioral or environmental differences.
This suggests that fundamental biological mechanisms contribute to elevated male mortality.
Our previous work implicated testicular factors as a major contributor, showing that prepubertal castration extends male lifespan to that of females in UM-HET3 mice, a genetically heterogeneous stock.
However, it remains unknown when testicular factors begin to exert their detrimental effects on mortality.
Here, we castrated UM-HET3 males before puberty (20 days), after puberty (60 days), or immediately before the typical rise in male mortality (240 days). Castration at all three ages prevented the early male mortality and increased median lifespan by 19.3%, 25.8%, and 32.9%, respectively.
The comparable survival benefits of prepubertal and postpubertal castration indicate that exposure to the pubertal surge in testicular factors, including male sex hormones, is not responsible for establishing the male longevity disadvantage. Remarkably, castration at 240 days not only preserved the survival benefit of earlier castration but produced significantly greater survival than earlier castration, suggesting that testicular exposure before 240 days is actually beneficial.
The immediate prevention of excess male mortality following castration at 240 days also indicates that the responsible testicular factors act rapidly and that their continued presence is necessary to sustain elevated male mortality.
Longitudinal body-composition measurements further revealed that castration shifted males toward a female-like phenotype, characterized by reduced lean mass and continued fat accumulation into later life.
Our findings reveal opposing age-dependent effects of testicular factors on survival and narrow the potential therapeutic window to later adulthood."
Castration extends life span, but in a surprising way, mouse study suggests "Scientists say work could help identify “castration mimetics” that boost longevity"
Beneficial early, harmful later: age-dependent effects of testicular factors on male mortality (preprint, open access)
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