Good news! Cancer is history (soon)!
"... A new study in the journal Immunity reveals that the prostate has its own defense force and unlocks key insights into how this army of cells, known as tissue-resident memory CD8 T cells, or Trm cells, works.
“We found that different types of T cells live in different areas, or neighborhoods, within the tissue, and where they live determines how they behave,” ..."
From the highlights and abstract:
"Highlights
• Long-lived prostate Trm cells protect against reinfection
• The prostate Trm population is heterogeneous in mice and humans
• IL-15, IL-7, and TGFβ differentially regulate prostate Trm cell subsets
• Distinct prostate cytokine and chemokine niches define Trm cell heterogeneity
Summary
The prostate is an important exocrine organ, a barrier tissue of the male reproductive system, and a common site of malignancy, yet CD8+ T cells in the prostate remain largely uncharacterized.
Here, we show that a protective, heterogeneous pool of long-lived, tissue-resident memory CD8+ T (Trm) cells forms in the prostate following acute infection in mice.
Characterization of prostate Trm cell differentiation over time, combined with functional interrogation of TGFβ, IL-7, and IL-15 signaling, revealed niche-dependent phenotypic and functional diversity arising from distinct prostate stromal and glandular epithelial niches in both mice and humans.
For instance, the Trm-promoting cytokines IL-15 and TGFβ were highest in the prostate epithelium, where CD8+ T cells were most persistent, cytotoxic, and enriched for the Trm molecular program.
In sum, we provide a spatial framework for prostate Trm cell differentiation, charting the discrete tissue regions that influence T cell fate through dynamic regulation of localized signals."
Distinct tissue niches contribute to prostate tissue-resident memory CD8+ T cell differentiation and heterogeneity (open access)
Graphical abstract
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