Good news!
"Researchers have developed a spray-on powder that turns into a wound-conforming gel when it comes in contact with blood. The breakthrough has the possibility of dramatically improving wound care in combat and other life-threatening situations. ...
Seeking a solution to treating such injuries, researchers at the Korea Advanced Institute of Science and Technology (KAIST), one of whom is an Army Major, developed a powder that reacts with cations (particles with a positive electrical charge) like calcium in blood to turn into a gel state in just one second, sealing even deep and irregular wounds instantly.
The substance is made from three natural ingredients: alginate, a substance extracted from brown seaweed; gellan gum, a natural thickener made from bacteria through fermentation; and chitosan, a powder made from the exoskeletons of crustaceans and insects as well as from fungal cell walls. ..."
"... Accordingly, the research team developed a next-generation hemostatic agent in powder form that can be freely applied even to deep, large, and irregular wounds. They have secured versatility to respond to various types of wounds with a single powder. ..."
From the abstract:
"Rapid and effective bleeding control remains a clinical priority, particularly for deep or irregular wounds where conventional dressings are inadequate.
Here, an ionically responsive, powder-based hemostatic system (AGCL) composed of alginate, gellan gum, chitosan, and a glutaraldehyde crosslinker is presented. Upon contact with calcium ions in blood, AGCL rapidly forms an adhesive hydrogel network within ≈1 s, enabling ultrafast gelation and a high blood uptake ratio (≈725%).
The powder exhibits strong bioadhesion (>40 kPa), excellent sealing under mixed-mode loading, and robust storage stability for up to 24 months under ambient conditions. In vitro assays confirm minimal hemolysis (<3%), high cytocompatibility, and greater than 99% antibacterial efficacy.
In various bleeding models, AGCL significantly reduced blood loss and time to hemostasis compared to TachoSil, a clinical benchmark.
Furthermore, AGCL accelerated re-epithelialization, angiogenesis, and collagen deposition in murine skin and liver wound models, supporting high-quality tissue regeneration without systemic toxicity.
These results demonstrate that AGCL integrates rapid coagulation, strong adhesion, long-term biostability, and regenerative capacity in a single platform.
Its powder format offers distinct advantages in versatility, ease of application, and storability, making it a promising candidate for next-generation topical hemostats in trauma care, surgery, and emergency medicine."
Hemostasis in 1 Second... Boosting Survival Rates for Soldiers (original news release)
Fig. 1 Fabrication and characterization of AGCL powder-type hemostatic material.
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