Amazing stuff! Good news!
"Microcirculation – the flow of blood through the smallest vessels – is responsible for distributing oxygen and nutrients to tissues and organs throughout the body. Mapping this flow at the whole-organ scale could enhance our understanding of the circulatory system and improve diagnosis of vascular disorders. With this aim, researchers at the Institute Physics for Medicine Paris ... have combined 3D ultrasound localization microscopy (ULM) with a multi-lens array method to image blood flow dynamics in entire organs with micrometric resolution, reporting their findings in Nature Communications. ..."
"Researchers develop an ultrasound probe capable of visualising an entire organ in 4D
For the first time, whole-organ blood flow dynamics can be mapped at micrometric resolution using an ultrasound multi-lens probe — demonstrated in vivo in the heart, kidney, and liver.
Developed at Physics for Medicine Paris, this technology enables real-time 4D imaging of vascular dynamics across entire organs. ..."
From the abstract:
"Mapping microcirculation at the whole-organ scale in 3D is crucial for understanding vascular pathologies and improving diagnostics. Although 3D ultrasound localization microscopy (ULM) enables microscopic resolution by localizing intravenously injected microbubbles in small animal models, visualizing entire organs in large animals or humans remains challenging due to limited field of view, low sensitivity, and probe technological complexity.
Here, we demonstrate how a multi-lens array method overcomes these limitations. Combined with 3D ULM, it maps and quantifies large vascular volumes (up to 120 × 100 × 82 mm³) at high spatial resolution (125–200 µm) with a volumetric acquisition rate of 312 Hz, using low-cost technology.
This approach enables deeper insights into hemodynamics from large vessels to pre-capillary arterioles, by providing vast and rich datasets of whole-organ vascularization.
It could also facilitate diagnosis of microcirculation disorders and monitoring of small-vessel disease treatments by addressing key limitations of current imaging modalities."
Major breakthrough in medical imaging just published in Nature Communications (original news release)
Multi-lens ultrasound arrays enable large scale three-dimensional micro-vascularization characterization over whole organs (open access)
Fig. 1: Definition, simulation study of the multi-lens array probe and comparison to conventional approaches.
Fig. 3: 3D Coronary mapping of an isolated porcine heart.
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