Good news! Amazing stuff! Cancer is history (soon)! See also the very impressive chart below.
Hopefully, this comprehensive, systematic and extensive review of current research will make a difference!
"Scientists found that nearly every cancer harbors its own distinct community of microbes – tiny passengers that can influence how tumors start, spread, and respond to treatment, paving the way for a new era of precision medicine. ...
A new study has summarized what’s currently known about the communities of microorganisms that live inside cancer tissue – the tumor microbiome – in different types of cancer. It looks at their influence on how cancers start, grow, spread, and respond to treatment – knowledge that could transform the way cancers are diagnosed, treated, and monitored in the era of precision medicine.
The researchers looked at findings by cancer type: breast, lung, prostate, pancreatic, stomach (gastric), bowel (colorectal), ovarian, melanoma, liver, esophageal, brain and bone cancers.
For each type, they determined the distinct microbial “signature.”
For example, lung tissue, once thought to be sterile, hosts microbes like Proteobacteria and Firmicutes, and cancerous lungs tend to have lower bacterial diversity, with Streptococcus and Neisseria often found in higher levels.
Prostate cancer contains a variety of microbes, especially Proteobacteria and Actinobacteria, and viruses and fungi are also found.
Ovarian tumors contain Firmicutes, Proteobacteria, Chlamydia, Mycoplasma, and various fungi; human papillomavirus (HPV) and cytomegalovirus (CMV) infections are frequent. ..."
From the abstract:
"Intra-tumoral microbes have been revealed to exist in many cancer types, attracting widespread attention. The significance of intra-tumoral microbes is becoming increasingly apparent in various aspects of human cancers, encompassing cancer initiation, progression, metastasis, diagnostic approaches, prognostic evaluations, and therapeutic interventions.
Despite the considerable focus dedicated to this topic by numerous scholars, a comprehensive analysis of intra-tumoral microbiota is still lacking in human cancers. Especially, identifying specific microbial hallmarks in the occurrence and development of cancer and different cancers remains the central task for investigators.
This review focuses on the identification and analysis of distinct attributes and noteworthy characteristics exhibited by intra-tumoral microbiota across various types of cancer. The potential mechanisms of intra-tumoral microbiota action, as well as the significance of the microbiome in the diagnosis and prognosis of cancer, are systematically summarized. The capacity of intra-tumoral microbes to regulate cancer treatment with a focus on the relevant microbial species, and the possibility of targeting the microbiota to improve treatment effectiveness while preventing toxicity, are specifically highlighted.
Lastly, the challenges, limitations, and prospects of intra-tumoral microbes in further study and clinical application, including prognostic, diagnostic, and therapeutic applications, are discussed in cancers.
This review provides a systematic summary of the specific characteristics, molecular mechanisms, therapeutic effects, and diagnostic and prognostic values of intra-tumoral microbiota in different cancers, which will help improve the diagnosis, treatment, and prognosis of tumor patients and offer new ideas for achieving precise treatment of cancer with intra-tumoral microbiota."
The specific hallmarks, emerging roles, key mechanisms, and clinical applications of intra-tumoral microbiota in human cancers (open access)
Figure 1. The characteristics of intra-tumoral microbiota in human different cancers. It was summarized based on the current reports of intra-tumoral microbiota in various cancer types, and the intra-tumoral microbiota has significant bacterial, viral, fungal, and parasitic signatures at phylum level.
BRCA, breast cancer; PRCA, prostate cancer; OVCA, ovarian cancer; PACA, pancreatic cancer; GACA, gastric cancer; CRCA, colorectal cancer; LUCA, lung cancer; MELA, melanoma; ESCA, esophageal cancer; BOCA, bone cancer; GLIO, glioblastoma multiforme; LICA, liver cancer; OSSA, oral squamous cell carcinoma.
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