The multiomics blueprint of the individual with the most extreme lifespan (died at age 117)

Amazing stuff! Scientists studied the genes of a woman (Maria Branyas Morera from Spain) who lived 117 years.

From the highlights and abstract:

"Highlights

• (Epi)genome, transcriptome, metabolome, proteome, and microbiome study of the oldest human

• Despite molecular hallmarks of aging, absence of major age-associated diseases

• Resilient genetic variants and low-inflammation metabolic profile reduce aging risks

• Bacteria occurrence and epigenome profile resembling younger individuals

Summary

Extreme human lifespan, exemplified by supercentenarians, presents a paradox in understanding aging: despite advanced age, they maintain relatively good health. To investigate this duality, we have performed a high-throughput multiomics study of the world’s oldest living person, interrogating her genome, transcriptome, metabolome, proteome, microbiome, and epigenome, comparing the results with larger matched cohorts.

The emerging picture highlights different pathways attributed to each process: the record-breaking advanced age is manifested by telomere attrition, abnormal B cell population, and clonal hematopoiesis, whereas absence of typical age-associated diseases is associated with rare European-population genetic variants, low inflammation levels, a rejuvenated bacteriome, and a younger epigenome. These findings provide a fresh look at human aging biology, suggesting biomarkers for healthy aging, and potential strategies to increase life expectancy. The extrapolation of our results to the general population will require larger cohorts and longitudinal prospective studies to design potential anti-aging interventions."

The multiomics blueprint of the individual with the most extreme lifespan - ScienceDirect

Maria Branyas Morera on her 117th birthday (Source)

Graphical abstract