Tuesday, July 08, 2025

Moss Medicines: The Next Revolution in Biotech?

Food for thought!

"... Unlike bacterial or yeast culture systems, mosses can produce complex glycosylated proteins that are often needed in biomedical applications. Another attractive feature is that moss species like Physcomitrella patens use homologous recombination to repair breaks in DNA, making it ideal for gene insertion.

Because of its favorable glycosylation profile, moss yielded a recombinant version of the human alpha galactosidase protein (aGal), which is used as an enzyme replacement therapy in the treatment of Fabry disease, a rare genetic disease. This moss-aGal protein, the first moss-produced drug, entered clinical trials in 2015. It even had a slight competitive edge over its human cell line-produced counterpart when tested in mice; by interacting with a different receptor, it was better able to target the kidney as well as the heart. ..."

Moss Medicines: The Next Revolution in Biotech? | The Scientist "Plant biotechnologists are favoring moss factories over other models to produce certain valuable proteins."


Physcomitrium patens is a species of moss frequently used in applied biotechnology to culture valuable compounds at scale.


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