Good news (for older, exercising males)!
"Exercise benefits — without the workout
When fed to mice, betaine — a modified amino acid made by the kidneys and involved in metabolism — can reproduce some of the benefits of exercise and slow some signs of ageing. Researchers found that old mice given water spiked with the molecule had stronger muscles, less inflammation and more youthful skin than their counterparts who did not get the supplement. Whether it would have the same effect in humans is unclear, but even if it did, it couldn’t replicate all of the myriad benefits of exercise ..."
From the highlights and abstract:
"Highlights
• Systematic molecular blueprint of how exercise reshapes human homeostasis
• Repeated exercise boosts circulating betaine partly via renal synthesis
• Betaine inhibits TBK1, reducing senescence and inflammation
• Betaine exerts multi-organ geroprotection in aged mice
Summary
Exercise has well-established health benefits, yet its molecular underpinnings remain incompletely understood. We conducted an integrated multi-omics analysis to compare the effects of acute vs. long-term exercise in healthy males.
Acute exercise induced transient responses, whereas repeated exercise triggered adaptive changes, notably reducing cellular senescence and inflammation and enhancing betaine metabolism.
Exercise-driven betaine enrichment, partly mediated by renal biosynthesis, exerts geroprotective effects and rescues age-related health decline in mice.
Betaine binds to and inhibits TANK-binding kinase 1 (TBK1), retarding the kinetics of aging. These findings systematically elucidate the molecular benefits of exercise and position betaine as an exercise mimetic for healthy aging."
Can a pill replace exercise? Swigging this molecule gives mice benefits of working out (behind paywall) "Betaine, a compound that becomes more abundant in men who take up jogging, could confer some of the anti-ageing advantages of physical activity."
Graphical abstract
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