Good news! Amazing stuff!
"A team of ... infectious diseases researchers recently conducted an in-depth review of the literature on how one genus of viruses, known as flaviviruses, manipulates mitochondria to evade immune responses. Annually, more than 3 billion people are at risk for flavivirus infection, which includes diseases such as yellow fever and dengue fever.
In their review ... the authors highlighted key mechanisms used by flaviviruses to evade host immune responses, such as the manipulation of mitochondrial fission and fusion processes to enhance replication, modulation of mitochondrial metabolic pathways, and effects on mitochondrial respiration. The work covered a wide scope of viruses within the genus, detailing the mechanisms used by Zika virus, dengue virus, Japanese encephalitis virus, West Nile virus, tick-borne encephalitis, and yellow fever virus. ..."
From the abstract (a disappointing, amateurish abstract):
"Mitochondria are essential eukaryotic organelles that regulate a range of cellular processes, from metabolism to calcium homeostasis and programmed cell death. They serve as essential platforms for antiviral signaling proteins during the innate immune response to viral infections. Mitochondria are dynamic structures, undergoing frequent fusion and fission processes that regulate various aspects of mitochondrial biology, including innate immunity. Pathogens have evolved sophisticated mechanisms to manipulate mitochondrial morphology and function to facilitate their replication. In this review, we examine the emerging literature on how flaviviruses modulate mitochondrial processes."
Fig. 1: Mitochondria play important roles in innate antiviral immune responses. Under stress conditions, such as those induced by viral infection, DNA is released from the mitochondria (mtDNA) and nucleus (dsDNA).
Fig. 2: Flaviviruses modulate mitochondrial fission and fusion dynamics.
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