Very recommendable! Amazing stuff! This research is dated from August 2023.
"According to a pair of new studies ... aging is evolutionary ... suggest that we evolved to age. ...
a “universal pan-mammalian epigenetic clock,” which is an assay that uses chemical changes in an animal’s DNA to predict that animal’s age. ...
The fact that this single clock works in mammals ranging from humans to mice to bowhead whales tells us something about why we age ...
“These mammalian species that we studied were separated by over 200 million years of evolution, and we have found one measurement that predicts their age,” ... In evolutionary terms, traits that are conserved are those that persist despite other changes evolution enacts over time. Things like hair or fur, warm-bloodedness, having four limbs — these are all conserved in mammals. And so, it turns out, is aging. ...
a “universal pan-mammalian epigenetic clock,” which is an assay that uses chemical changes in an animal’s DNA to predict that animal’s age. ...
The fact that this single clock works in mammals ranging from humans to mice to bowhead whales tells us something about why we age ...
“These mammalian species that we studied were separated by over 200 million years of evolution, and we have found one measurement that predicts their age,” ... In evolutionary terms, traits that are conserved are those that persist despite other changes evolution enacts over time. Things like hair or fur, warm-bloodedness, having four limbs — these are all conserved in mammals. And so, it turns out, is aging. ...
The molecular clock works by tracking age-related changes to our DNA known as methylation. This modification is a tiny chemical addition to one of the letters of DNA’s backbone. DNA methylation serves a variety of biological purposes, but for the case of the molecular clock, what’s important is that it changes with age. Some regions of our genome increase their methylation as we get older, others decrease. ...
In 2011, ... discovered that age-related changes in DNA methylation are consistent enough to accurately predict humans’ age based on a saliva sample. Two years later ... demonstrated the same thing in all human tissue types, including blood and organ biopsies. ...
In 2011, ... discovered that age-related changes in DNA methylation are consistent enough to accurately predict humans’ age based on a saliva sample. Two years later ... demonstrated the same thing in all human tissue types, including blood and organ biopsies. ...
over the past seven years ... has studied molecular aging in humans, capybaras, ring-tailed lemurs, horses and sea lions. He has collaborators from six continents. ... Ultimately, he ended up collecting samples from 348 different species of mammals. The pan-mammalian clock constructed ... uses samples from 185 of those species. In another study ... showed that they can use DNA methylation patterns as a proxy for evolution. Modern evolutionary biologists create evolutionary trees of different species by comparing their DNA sequences. It turns out that DNA methylation patterns work just as well — the family trees ... constructed matched those traditionally made using DNA alone. ..."
Note: Unfortunately, the article below does not seem to provide links to the two new research papers featured in this article!
A new biological clock ... predicts the age of hundreds of species of mammals. In this figure, mammal species are arranged by their maximum lifespan (black dashed line), from lowest (the cinerus shrew) to highest (bowhead whale). The red and purple lines show the accuracy of the molecular clock per species.
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