Saturday, October 29, 2022

Engineered porous silica made from purified sand gain momentum as obesity treatment

Good news! Sounds simple, safe, and convenient! It appears that several studies have now confirmed these results.

"... A new study has bolstered the potential of silica particles made from this material by showing how they block enzyme activity to hamper the body’s uptake of fats and sugars, while also hinting at the ideal design for the optimal anti-obesity effects. ...
The research ... builds on earlier work exploring how engineered silica particles can impact the way the body absorbs energy from high-fat foods. Previous studies have shown mesoporous silica particles can drive weight loss in obese mice when added to their diet, and can be safely tolerated in male humans as a food additive. One 2020 paper also hinted at the best shape and size of particle to induce anti-obesity effects. ...
"... research shows how porous silica promotes an anti-obesity effect by functioning locally in the gut to restrict fat and carbohydrate digestion and absorption. Importantly, the gentle mechanism is expected to deliver clinically effective outcomes for weight loss, without adverse effects.” ...
by hampering activity of digestive enzymes called α-Amylas and pancreatic lipase in the gastrointestinal tract ..."

From the abstract:
"The potential for porous silica to serve as an effective anti-obesity agent has received growing attention in recent years. However, neither the exact pharmacological mechanism nor the fundamental physicochemical properties of porous silica that drive its weight-lowering effect are well understood. Subsequently, in this study, an advanced in vitro digestion model capable of monitoring lipid and carbohydrate digestion was employed to elucidate the effect of porous silica supplementation on digestive enzyme activities. A suite of porous silica samples with contrasting physicochemical properties was investigated, where it was established that the inhibitory action of porous silica on digestive enzyme functionality was strongly dependent on porous nanostructure, particle size and morphology, and surface chemistry. Insights derived from this study validate the capacity of porous silica to impede the digestive processes mediated by pancreatic lipase and α-amylase within the gastrointestinal tract, while the subtle interplay between porous nanostructure and enzyme inhibition indicates that the anti-obesity effect can be optimized through strategic particle design."

Particles made from purified sand gain momentum as obesity treatment




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