Saturday, September 03, 2022

Making oxygen injectable into the human body

Amazing stuff! Could become a life safer!

"... a new approach to transporting gases in aqueous environments using porous liquids. The authors identified and tailored multiple porous frameworks that can store much higher concentrations of gases, including oxygen (O2) and carbon dioxide (CO2), than normal aqueous solutions. This breakthrough may hold the key to creating injectable sources of oxygen as a bridge therapy for cardiac arrest, creating artificial blood substitutes, and overcoming longstanding challenges in preserving organs for transplants. ...
Liquids with permanent microporosity are a new class of materials that are composed of microscopic porous particles dispersed in a liquid medium. ..."

From the abstract:
"Liquids with permanent microporosity can absorb larger quantities of gas molecules than conventional solvents, providing new opportunities for liquid-phase gas storage, transport and reactivity. ... Here we report a generalizable thermodynamic strategy to preserve permanent microporosity and impart high gas solubilities to liquid water. Specifically, we show how the external and internal surface chemistry of microporous zeolite and metal–organic framework (MOF) nanocrystals can be tailored to promote the formation of stable dispersions in water while maintaining dry networks of micropores that are accessible to gas molecules. As a result of their permanent microporosity, these aqueous fluids can concentrate gases, including oxygen (O2) and carbon dioxide (CO2), to much higher densities than are found in typical aqueous environments. When these fluids are oxygenated, record-high capacities of O2 can be delivered to hypoxic red blood cells, highlighting one potential application of this new class of microporous liquids for physiological gas transport."

Designing a way to make oxygen injectable – Harvard Gazette Porous liquids hold promise as bridge therapy, game-changer for artificial blood substitutes, preserving organs for transplant




No comments: