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"... In a new study, they found that removing the enzyme from neurons in a part of the brain known as the hypothalamus led mice to gain weight and burn less fat. This finding, they say, suggests that the enzyme could be a target for treating metabolic disease. ...
For the study, Yale researchers focused on an enzyme called O-linked b-D-N-acetylglucosamine transferase, or OGT. ...
For the study, Yale researchers focused on an enzyme called O-linked b-D-N-acetylglucosamine transferase, or OGT. ...
As a first step, researchers observed what happened to OGT in neurons of the ventromedial hypothalamus when food intake was adjusted. They found that when mice consumed less food, OGT levels went up. ...
... bred mice that lacked OGT in neurons of the ventromedial hypothalamus. They found that the mice gained weight very quickly on a normal diet, becoming much heavier than typical mice even though they were eating the same amount of food and were just as physically active. ...
But in the study, mice lacking OGT didn’t burn fat as much as other mice when food was restricted. ..."
... bred mice that lacked OGT in neurons of the ventromedial hypothalamus. They found that the mice gained weight very quickly on a normal diet, becoming much heavier than typical mice even though they were eating the same amount of food and were just as physically active. ...
But in the study, mice lacking OGT didn’t burn fat as much as other mice when food was restricted. ..."
From the abstract:
"The ventromedial hypothalamus (VMH) is known to regulate body weight and counterregulatory response. However, how VMH neurons regulate lipid metabolism and energy balance remains unknown. O-linked β-D-N-acetylglucosamine (O-GlcNAc) modification (O-GlcNAcylation), catalyzed by O-GlcNAc transferase (OGT), is considered a cellular sensor of nutrients and hormones. Here, we report that genetic ablation of OGT in VMH neurons inhibits neuronal excitability. Mice with VMH neuron-specific OGT deletion show rapid weight gain, increased adiposity, and reduced energy expenditure, without significant changes in food intake or physical activity. The obesity phenotype is associated with adipocyte hypertrophy and reduced lipolysis of white adipose tissues. In addition, OGT deletion in VMH neurons down-regulates the sympathetic activity and impairs the sympathetic innervation of white adipose tissues. These findings identify OGT in the VMH as a homeostatic set point that controls body weight and underscore the importance of the VMH in regulating lipid metabolism through white adipose tissue–specific innervation."
Fig. 8. OGT is required for the neuronal activity of the VMH.
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