Very recommendable! Potentially, a breakthrough in defeating antibiotic resistance! Very nice interdisciplinary research!
"Bacteria may be most dangerous when they connect -- banding together to build fortress-like structures known as biofilms that afford them resistance to antibiotics. ...
Further analysis suggested the enzyme first helps the antibiotic kill the bacteria in the oxygenated outer regions of the biofilm in a way that had not before been seen, leading, in short time, to a significant reduction in the total number of viable biofilm cells. ..."
Further analysis suggested the enzyme first helps the antibiotic kill the bacteria in the oxygenated outer regions of the biofilm in a way that had not before been seen, leading, in short time, to a significant reduction in the total number of viable biofilm cells. ..."
"Pseudomonas aeruginosa is a major cause of hospital-acquired infections due to its formation of biofilms that are highly tolerant to antibiotics. ...
One way in which P. aeruginosa builds robust biofilms is through the production of redox-active phenazines such as pyocyanin. We identified an enzyme that degrades pyocyanin but were stymied in studying its potential to combat biofilms due to its poor expression yield. Here we show how protein design can stabilize the enzyme to improve purification yields, enabling physiological studies to reveal a novel enzyme’s therapeutic potential. ..."
One way in which P. aeruginosa builds robust biofilms is through the production of redox-active phenazines such as pyocyanin. We identified an enzyme that degrades pyocyanin but were stymied in studying its potential to combat biofilms due to its poor expression yield. Here we show how protein design can stabilize the enzyme to improve purification yields, enabling physiological studies to reveal a novel enzyme’s therapeutic potential. ..."
Unfortunately, the link to the underlying research article was not provided. Here is what I believe the link is:
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