Bad news for olive oil! Cancer is history (soon)!
Olive oil gets a bad rap here, while e.g. fish oil is more beneficial.
"... The research ... shows that for pancreatic cancer, the type of fat you consume matters more than the amount. ...
One fat in particular—oleic acid, the primary fatty acid in olive oil—may be accelerating tumor growth in ways scientists never anticipated. The result was surprising given oleic acid's reputation in medicine. "It's traditionally been considered a healthy type of fat for cardiovascular health," ...
Pancreatic ductal adenocarcinoma (PDAC) ...
Fat can be protective against cancer
To find out the effects of each fat, ... designed a comprehensive dietary screen using 12 high-fat diets, each identical in caloric content but differing solely in fat source. The diets were modeled on real patterns of modern American fat consumption. ...
for decades, the research community broadly “gave mice very high levels of fat in their diet, often using a single fat source.” Most prior studies used lard-based diets at 60% fat by calories—a formulation that neither reflects what most people actually eat nor isolates the effects of specific fatty acids.
“Exactly what components of dietary fat cause cancer has remained a mystery,” ...
What the team found was striking. Diets rich in oleic acid—a monounsaturated fatty acid (MUFA) found in, among other foods, olive oil, high-oleic safflower oil, high-oleic sunflower oil, peanuts, and lard—significantly accelerated tumor development in mice carrying a genetic mutation that leads to illness closely mimicking human PDAC development.
However, diets high in polyunsaturated fatty acids (PUFAs) suppressed it, especially omega-3 fatty acids, such as those found in fish oil."
From the abstract:
"High-fat diet (HFD) intake has been linked to an increased risk of pancreatic ductal adenocarcinoma (PDAC), a lethal and therapy-resistant cancer.
However, whether and how specific dietary fats drive cancer development remains unresolved.
Leveraging an oncogenic Kras-driven mouse model that closely mimics human PDAC progression, we screened a dozen isocaloric HFDs differing solely in fat source and representing the diversity of human fat consumption.
Unexpectedly, diets rich in oleic acid – a monounsaturated fatty acid (MUFA) typically associated with good health – markedly enhanced tumorigenesis. Conversely, diets high in polyunsaturated fatty acids (PUFAs) suppressed tumor progression.
Relative dietary fatty acid saturation levels (PUFA/MUFA) governed pancreatic membrane phospholipid composition, lipid peroxidation, and ferroptosis sensitivity in mice, concordant with circulating PUFA/MUFA levels being linked to altered PDAC risk in humans.
These findings directly implicate dietary unsaturated fatty acids in controlling ferroptosis susceptibility and tumorigenesis, supporting potential “precision nutrition” strategies for PDAC prevention."
Diet-induced phospholipid remodeling dictates ferroptosis sensitivity and tumorigenesis in the pancreas (no public access)
Diet-induced phospholipid remodeling dictates ferroptosis sensitivity and tumorigenesis in the pancreas (preprint, open access)
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