Exercise more!
"... Worldwide incidence of cancer in people under 50 rose by nearly 80%(link is external and opens in a new window) from 1990 to 2019, according to the Global Burden of Disease(link is external and opens in a new window) study. Out of 29 types of cancer in the analysis, early-onset breast cancer had both the highest incidence and mortality. ...
Research has long shown that regular exercise can lower the risk of breast cancer and other types of cancer. But when does physical activity make the biggest impact? A recent study(link is external and opens in a new window) by Kehm and her colleagues focused on specific “windows of time” in life to see how exercise might influence breast cancer risk. The study found that staying active during adolescence and early adulthood can significantly reduce the risk of developing breast cancer before age 40. ...
Women who were highly active during both adolescence and early adulthood had a 22% lower risk of early-onset breast cancer compared with women who were not highly active during either time period.
“Physical activity can be important for hormone regulation, so it can lower estrogen levels in individuals, which reduces risk for cancer,” ... reducing chronic inflammation and oxidative stress.” ..."
From the abstract:
"Background: Breast cancer incidence is increasing in women under age 40, underscoring the need for research on breast cancer risk factors for younger women.
Methods: We used data from an international family cohort (n = 26,348) to examine whether recreational physical activity (RPA) during adolescence and early adulthood is associated with breast cancer risk before age 40. The cohort includes 2,502 women diagnosed with breast cancer before age 40, including 2,408 diagnosed before study enrollment (68% within 5 years of enrollment). Women reported their average hours per week of moderate and strenuous RPA during adolescence (12-17 years) and early adulthood (25-34 years), which were converted to total age-adjusted metabolic equivalents per week and categorized into quartiles. We conducted attained age analyses until age 40 (follow-up time began at age 18) using Cox proportional hazards regression models adjusted for study center, race and ethnicity, and education.
Results: Being in the highest versus lowest quartile of RPA during adolescence and early adulthood were respectively associated with 12% [HR (95% confidence interval, or CI), 0.88 (0.78-0.98)] and 16% [HR (95% CI), 0.84 (0.74-0.95) lower breast cancer risks before age 40. Being in the highest quartile of RPA during both adolescence and early adulthood (Pearson correlation = 0.52) versus neither time point was associated with a 22% lower risk [HR (95% CI), 0.78 (0.68-0.89)].
Conclusions: Findings suggest that RPA during adolescence and early adulthood may lower breast cancer risk before age 40. ..."
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