Good news! Don't ever give up on the fountain of youth!
This could be a major breakthrough!
For how long can God keep a secret like longevity? Humans are pregnant with ideas! Caution: Satire
"... In 2012 Danish neuroscientist, Maiken Nedergaard first described the system that uses cerebrospinal fluid (CSF) to remove waste from the brain and termed it the glymphatic system.
Now, Nedergaard and her colleagues have looked deeper into the glymphatic system, focusing on lymph vessels called lymphangions. These are a series of tiny pumps in the neck that are responsible for moving dirty CSF out of the brain and into the lymph system where it ultimately reaches the kidneys to be processed. ...
Using advanced particle tracking in mice models, they found that as the rodents aged, the contractions in these pumps decreased. As a result, they found that older mice had 63% less dirty CSF flowing out of their brains compared to younger mice ...
Nedergaard focused on the fact that lymphangions are lined with smooth muscle cells. So they looked to a drug called prostaglandin F2α, which works on these types of cells and is commonly used to induce labor in pregnant women. ... administering the drug to the elderly mice with a topical cream got the pumps working again to the point that the team saw the flow of dirty CSF out of the brain return to the same level of efficiency seen in younger mice. ..."
Now, Nedergaard and her colleagues have looked deeper into the glymphatic system, focusing on lymph vessels called lymphangions. These are a series of tiny pumps in the neck that are responsible for moving dirty CSF out of the brain and into the lymph system where it ultimately reaches the kidneys to be processed. ...
Using advanced particle tracking in mice models, they found that as the rodents aged, the contractions in these pumps decreased. As a result, they found that older mice had 63% less dirty CSF flowing out of their brains compared to younger mice ...
Nedergaard focused on the fact that lymphangions are lined with smooth muscle cells. So they looked to a drug called prostaglandin F2α, which works on these types of cells and is commonly used to induce labor in pregnant women. ... administering the drug to the elderly mice with a topical cream got the pumps working again to the point that the team saw the flow of dirty CSF out of the brain return to the same level of efficiency seen in younger mice. ..."
"Alzheimer’s, Parkinson’s, and other neurological disorders can be seen as “dirty brain” diseases, where the brain struggles to clear out harmful waste. Aging is a key risk factor because, as we grow older, our brain's ability to remove toxic buildup slows down. However, new research in mice demonstrates that it’s possible to reverse age-related effects and restore the brain’s waste-clearing process. ..."
From the abstract:
"Cervical lymphatic vessels (cLVs) have been shown to drain solutes and cerebrospinal fluid (CSF) from the brain. However, their hydrodynamical properties have never been evaluated in vivo. Here, we developed two-photon optical imaging with particle tracking in vivo of CSF tracers (2P-OPTIC) in superficial and deep cLVs of mice, characterizing their flow and showing that the major driver is intrinsic pumping by contraction of the lymphatic vessel wall. Moreover, contraction frequency and flow velocity were reduced in aged mice, which coincided with a reduction in smooth muscle actin expression. Slowed flow in aged mice was rescued using topical application of prostaglandin F2α, a prostanoid that increases smooth muscle contractility, which restored lymphatic function in aged mice and enhanced central nervous system clearance. We show that cLVs are important regulators of CSF drainage and that restoring their function is an effective therapy for improving clearance in aging."
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