Good news! Amazing stuff!
"Researchers from Tel Aviv University and the Israel Institute for Biological Research have developed an mRNA-based vaccine found to be 100 percent effective against a deadly type of bacteria when tested in lab animals.
According to the researchers, their new technology can enable rapid development of effective vaccines for bacterial diseases, including diseases caused by antibiotic-resistant bacteria. ..."
From the abstract:
"Messenger RNA (mRNA) lipid nanoparticle (LNP) vaccines have emerged as an effective vaccination strategy. Although currently applied toward viral pathogens, data concerning the platform’s effectiveness against bacterial pathogens are limited. Here, we developed an effective mRNA-LNP vaccine against a lethal bacterial pathogen by optimizing mRNA payload guanine and cytosine content and antigen design. We designed a nucleoside-modified mRNA-LNP vaccine based on the bacterial F1 capsule antigen, a major protective component of Yersinia pestis, the etiological agent of plague. Plague is a rapidly deteriorating contagious disease that has killed millions of people during the history of humankind. Now, the disease is treated effectively with antibiotics; however, in the case of a multiple-antibiotic-resistant strain outbreak, alternative countermeasures are required. Our mRNA-LNP vaccine elicited humoral and cellular immunological responses in C57BL/6 mice and conferred rapid, full protection against lethal Y. pestis infection after a single dose. These data open avenues for urgently needed effective antibacterial vaccines."
A single-dose F1-based mRNA-LNP vaccine provides protection against the lethal plague bacterium (open access)
Fig. 1. Construct design, physicochemical characterization of mRNA-LNPs formulations used throughout the study, and immunological responses elicited by SP-cp-caf1 mRNA-LNPs.
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