Good news! What a data intensive study! It seems this study has not yet even involved machine/deep learning. More to come ...
"Around 10 percent of people say they’ve had an allergic reaction to penicillin, according to the U.S. Centers for Disease Control and Prevention. Now researchers have found a genetic link to the hypersensitivity, which, while rarely fatal, can cause hives, wheezing, arrythmias and more. ...
That hot spot is on the major histocompatibility complex gene HLA-B [human leukocyte antigen (HLA)] ...
Several recent studies have connected distinct differences in HLA genes to bad reactions to specific drugs. For example, studies have linked an HLA-B variant to adverse reactions to an HIV/AIDS medication called abacavir, and they’ve linked a different HLA-B variant to allergic reactions to the gout medicine allopurinol. ...
For the penicillin study, the team hunted through more than 600,000 electronic health records that included genetic information for people who self-reported penicillin allergies. The researchers used several genetic search tools, which comb through DNA in search of genetic variations that may be linked to a health problem. Their search turned up a specific spot on chromosome 6, on a variant called HLA-B*55:01. ...
The group then checked its results against 1.12 million people of European ancestry in the research database of the genetic-testing company 23andMe and found the same link. A check of smaller databases including people with East Asian, Middle Eastern and African ancestries found no similar connection, although those sample sizes were too small to be sure ...
That hot spot is on the major histocompatibility complex gene HLA-B [human leukocyte antigen (HLA)] ...
Several recent studies have connected distinct differences in HLA genes to bad reactions to specific drugs. For example, studies have linked an HLA-B variant to adverse reactions to an HIV/AIDS medication called abacavir, and they’ve linked a different HLA-B variant to allergic reactions to the gout medicine allopurinol. ...
For the penicillin study, the team hunted through more than 600,000 electronic health records that included genetic information for people who self-reported penicillin allergies. The researchers used several genetic search tools, which comb through DNA in search of genetic variations that may be linked to a health problem. Their search turned up a specific spot on chromosome 6, on a variant called HLA-B*55:01. ...
The group then checked its results against 1.12 million people of European ancestry in the research database of the genetic-testing company 23andMe and found the same link. A check of smaller databases including people with East Asian, Middle Eastern and African ancestries found no similar connection, although those sample sizes were too small to be sure ...
Penicillin allergies often begin in childhood, but can wane over time, making the drugs safer to use some years later, ...
The distinction matters, because about 90 percent of patients who claim to be allergic to penicillin can actually safely take the drug ...""... We also observed a significant hit in PTPN22 and the GWAS results correlated with the genetics of rheumatoid arthritis and psoriasis. ..."
Here is the respective research paper:
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