Good news! Cancer is history (soon)!
"Designer CAR Ts keep blood cancer at bay
Switching out letters in the genetic code of CAR T cells has put 7 out of 11 people with a type of blood cancer known as acute lymphoblastic leukemia into remission. The pioneering treatment uses CRISPR to make three base edits in the DNA of donor CAR T cells. These edits make it possible for the CAR T cells to seek out and destroy cancerous T cells while shielding themselves from attack from the immune system and chemotherapy. ..."
From the abstract:
"Abstract
Background
CD7 is an attractive target for chimeric antigen receptor (CAR) T-cell therapy in relapsed or refractory T-cell acute lymphoblastic leukemia (ALL). Supportive results of first-in-human studies of base-edited anti-CD7 CAR (BE-CAR7) T cells with triple C→T deamination-mediated knockouts of TCRαβ, CD52, and CD7 have been reported previously.
Methods
In a phase 1 study, we administered BE-CAR7 T cells to children (≤16 years of age) with relapsed or refractory T-cell ALL after they had undergone lymphodepletion with fludarabine, cyclophosphamide, and alemtuzumab. Adults with compassionate-use access arrangements were also eligible. Patients who had remission by day 28 after the BE-CAR7 T-cell infusion proceeded to allogeneic hematopoietic stem-cell transplantation. The primary outcome was safety. Secondary outcomes included duration of remission, disease-free survival, and overall survival.
Results
BE-CAR7 T cells were administered to 9 children, as well as to 2 adults who were treated under compassionate-use access arrangements. Lymphodepletion and BE-CAR7 infusions did not lead to unacceptable adverse events, and circulating CAR7 T cells were detected in all the patients.
Complications included cytokine release syndrome of grades 1 through 4, transient rashes, multilineage cytopenia, and opportunistic infections.
All the patients had complete morphologic remission with incomplete count recovery at day 28.
Nine patients (82%) had deep remission (according to flow cytometry or polymerase-chain-reaction assay) that allowed them to proceed to stem-cell transplantation, and 2 patients with quantifiable minimal residual disease in bone marrow received palliative care.
Transplantation eliminated remaining BE-CAR7 T cells and supported donor-derived, multilineage reconstitution.
Viral reactivations were frequent, and 3 patients had clinically significant virus-related complications after transplantation.
Overall, 7 of the 11 patients (64%) who received the investigational therapy were in ongoing remission at 3 to 36 months after transplantation, and leukemia with loss of CD7 expression was documented in 2 patients.
Transplantation eliminated remaining BE-CAR7 T cells and supported donor-derived, multilineage reconstitution.
Viral reactivations were frequent, and 3 patients had clinically significant virus-related complications after transplantation.
Overall, 7 of the 11 patients (64%) who received the investigational therapy were in ongoing remission at 3 to 36 months after transplantation, and leukemia with loss of CD7 expression was documented in 2 patients.
Conclusions
Universal BE-CAR7 T cells induced leukemic remission in patients with relapsed or refractory T-cell ALL, thus allowing successful allogeneic hematopoietic stem-cell transplantation in most of the patients. ..."
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