Good news!
"“Surgeons in China have for the first time transplanted a section of liver extracted from a genetically modified pig into a human cancer patient ...
The surgeons, who described the procedure in a paper in The Journal of Hepatology, grafted the portion of pig liver onto the left lobe of a 71-year-old patient’s liver after removing the larger right lobe, where a tumor the size of a grapefruit had grown. The lobe with the porcine transplant functioned, producing bile and synthesizing blood clotting factors, the surgeons reported. The patient’s body did not reject the organ graft, which enabled the remaining left lobe of the patient’s own liver to regenerate and grow, the scientists said.
The porcine liver lobe was removed 38 days after the transplant, when complications developed, the surgeons wrote in the report. The patient, who had advanced disease, died a little over five and a half months later. ..."
From the highlights and abstract:
"Highlights
• First successful auxiliary porcine liver xenotransplantation from a 10-gene edited pig to a living recipient, distinct from prior brain-dead recipient cases.
• Porcine albumin and coagulation factors were bioactive, sustaining hepatic metabolic function without allergic reactions or other adverse effects.
• Early postoperative course showed no hyperacute or acute rejection, supporting the effectiveness of donor gene editing and immunosuppression.
• Xenotransplantation-associated thrombotic microangiopathy (xTMA) was successfully controlled by graft removal, followed by eculizumab and plasma exchange.
• Establishes auxiliary liver xenotransplantation as a life-saving bridge for unresectable liver cancer or liver failure, and provides a clinical paradigm for future liver xenotransplantation trials.
Abstract
Background
The advent of genetically edited porcine-to-human xenotransplantation has predominantly focused on cardiac and renal applications, with no reported cases of porcine-to-human liver xenotransplantation. This study presents the world’s first successful genetically modified pig auxiliary liver xenotransplantation in a living human, achieving an unprecedented survival of 171 days, and provides valuable insights into the critical factors influencing the procedure’s success.
Methods
A genetically modified pig liver, incorporating 10 targeted gene edits, was transplanted as an auxiliary organ into a patient with large hepatocellular carcinoma in the right hepatic lobe, which was initially deemed ineligible for curative resection. Liver function, metabolic, and coagulation markers were closely monitored throughout the perioperative period.
Results
For the first 31 days post-transplant, no hyperacute or acute rejection, infections, or significant complications were observed, and the patient’s hepatic and renal functions remained stable.
Early postoperative coagulopathy, as indicated by elevated D-dimer and fibrin degradation products, was successfully managed through anticoagulant therapy. However, on postoperative day 38, the auxiliary liver was removed due to xenotransplantation-associated thrombotic microangiopathy (xTMA). Subsequent management with eculizumab and plasma exchange successfully resolved the xTMA. Unfortunately, repeated upper gastrointestinal hemorrhage ultimately led to the patient's death on day 171.
Conclusions
This study demonstrates the feasibility of auxiliary porcine liver xenotransplantation as a bridging approach to human to liver transplantation. Postoperative xTMA presents a significant challenge to long-term success, highlighting the need for further research to improve xenotransplantation outcomes.
Impact and implications
This study reports the world’s first auxiliary xenotransplantation from a 10-gene-edited pig to a living human recipient - distinct from previous studies involving brain-dead donors.
The donor liver was engineered using a 10-gene editing platform, including the knockout of xenoantigen genes and the knock-in of seven human transgenes for immune and coagulation compatibility - pushing the boundaries of synthetic biology in clinical transplantation.
The porcine graft exhibited metabolically active liver function, bile secretion, and coagulation correction, demonstrating not only survival but clinically meaningful function.
Our work documents, for the first time, xenotransplantation-associated thrombotic microangiopathy (xTMA) in a living human recipient, with comprehensive immunological and histopathological analysis - critical knowledge for the field."
Graphical abstract
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