Amazing stuff! About the fine line between sanity and madness! Which genes make you happy! 😊
Unfortunately, I was not able to find e.g. an original news release for this study, which is unusual. I suspect, research produced in South Korea is still not very well accessible.
"In psychology, the term subjective well-being (SWB) is used to describe the extent to which different people feel happy and satisfied with their lives. While some studies have found that there is a link between SWB and the diagnosis of some psychiatric disorders, such as depression and anxiety disorders, their possible genetic commonalities have not yet been clearly delineated.
Researchers ... recently carried out a study aimed at better understanding the genes that could contribute to people's feelings of happiness and life satisfaction, as well as their possible connection to psychiatric disorders.
Their findings ... pin-point some brain tissues and genes linked to SWB, suggesting that they might also play a part in the development of psychiatric disorders. ...
For instance, the team found that approximately 93% of the genetic variants linked to depression were also tied to how happy people feel in their everyday lives. ..."
From the abstract:
"Subjective well-being (SWB) is important for understanding human behaviour and health. Although the connection between SWB and psychiatric disorders has been studied, common genetic mechanisms remain unclear. This study aimed to explore the genetic relationship between SWB and psychiatric disorders. Bivariate causal mixture modelling (MiXeR), polygenic risk score (PRS) and Mendelian randomization (MR) analyses showed substantial polygenic overlap and associations between SWB and the psychiatric disorders.
Subsequent replication studies in East Asian populations confirmed the polygenic overlap between schizophrenia and SWB.
The conditional and conjunctional false discovery rate analyses identified additional or shared genetic loci associated with SWB or psychiatric disorders. Functional annotation revealed enrichment of specific brain tissues and genes associated with SWB.
The identified genetic loci showed cross-ancestry transferability between the European and Korean populations. Our findings provide valuable insights into the common genetic mechanisms underlying SWB and psychiatric disorders."
No comments:
Post a Comment