Amazing stuff! Poor sleep or sleep loss is perhaps worse for your health than you thought! It is diabolic!
"... There are a million reasons why we don’t get as much sleep as we should. And that’s not just making us tired—it’s making us ill ... “Sleep loss can be aptly defined as a metabolic disorder,” ...
“ With wakefulness, we are creating all sorts of metabolic waste,” ... “And then when we sleep, we know that we are able to clear some of that cellular metabolite waste that we have generated throughout the day.” ...
outline all sorts of additional ways that cells behave differently on too little sleep, many of which impair the production of cellular fuel. “What we are trying to highlight is, truly, how profound those changes are in the cells of our body and brain,” ... “ to the point that perhaps we shouldn’t dismiss our sleep so easily.”"
From the abstract:
"Sleep loss dysregulates cellular metabolism and energy homeostasis. Highly metabolically active cells, such as neurons, enter a catabolic state during periods of sleep loss, which consequently disrupts physiological functioning.
Specific to the central nervous system, sleep loss results in impaired synaptogenesis and long-term memory, effects that are also characteristic of neurodegenerative diseases.
In this review, we describe how sleep deprivation increases resting energy expenditure, leading to the development of a negative energy balance—a state with insufficient metabolic resources to support energy expenditure—in highly active cells like neurons.
This disruption of energetic homeostasis alters the balance of metabolites, including adenosine, lactate, and lipid peroxides, such that energetically costly processes, such as synapse formation, are attenuated. During sleep loss, metabolically active cells shunt energetic resources away from those processes that are not acutely essential, like memory formation, to support cell survival. Ultimately, these findings characterize sleep loss as a metabolic disorder."
Sleep loss is a metabolic disorder (a review, no public access)
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